SCTCi019-B

A P E C

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iPSC Line
hPSCreg name	SCTCi019-B
Cite as:	SCTCi019-B (RRID:CVCL_C6SF)
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	No similar lines found.
Last update	31st July 2023
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Provider
Generator	Radboudumc Stem Cell Technology Center (SCTC)
External iPSC Databases
Cellosaurus	CVCL_C6SF
Wikidata	Q117704850
General iPSC Information
Publications	Schuurmans IME et al. Generation of an induced pluripotent stem cell line carrying biallelic deletions (SCTCi019-B) in ALDH7A1 using CRISPR/Cas9. Stem cell research. 2023 Sep;71:103173. Schuurmans IME et al. Generation of hiPSC lines from four pyridoxine-dependent epilepsy (PDE) patients carrying the variant c.1279G>C in ALDH7A1 in homozygosis. Stem cell research. 2024 Sep;79:103480. van Karnebeek Clara D M et al. New treatment for pyridoxine-dependent epilepsy due to ALDH7A1 deficiency: first proof-of-principle of upstream enzyme inhibition in the mouse. Brain Communications. 2025-10-30. Schuurmans IME et al. Targeting AASS alleviates neurotoxicity and improves mitochondrial function in astrocyte models for pyridoxine-dependent epilepsy. Molecular therapy. Nucleic acids. 2025 Dec 9;36(4):102728.