The role of small non-coding RNAs during early mesoderm and hematopoietic differentiation
|Title||The role of small non-coding RNAs during early mesoderm and hematopoietic differentiation|
|Sponsor||European Union's Seventh Framework Programme (FP7)|
|Institution||University of Oslo|
Associated cell lines
Human embryonic stem cells can be expanded and remain pluripotent when cultured under defined conditions. When exposed to differentiation signals pluripotent cells can give rise to somatic cell types found in the adult body, properties that make these cells an interesting source for regenerative medicine. Small, non-coding RNAs are molecules that are known to play important roles in regulating cellular processes during development. Little is however known about which non-coding RNAs are necessary for the efficient differentiation of blood progenitor cells from pluripotent stem cells in vitro. I propose to combine a bioinformatics approach using a defined cell culture system to identify novel key players needed for efficient in vitro derivation of blood cells.