Publications associated with registered cell lines
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Federico González-Pozas, Rosa Montes, Joan Domingo-Reinés, Verónica Ayllón, Verónica Ramos-Mejía
Hoxa9 and EGFP reporter expression in human Embryonic Stem Cells (hESC) as useful tools for studying human development
2017-08-05 00:00:00.0 5th Aug 2017Journal etc.
DOI: 10.1016/j.scr.2017.08.004Associated cell lines:
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Sylvia Merkert, Christien Bednarski, Gudrun Göhring, Toni Cathomen, Ulrich Martin
Generation of a gene-corrected isogenic control iPSC line from cystic fibrosis patient-specific iPSCs homozygous for p.Phe508del mutation mediated by TALENs and ssODN
2017-08-01 00:00:00.0 1st Aug 2017Journal etc.
DOI: 10.1016/j.scr.2017.07.010Associated cell lines:
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Yingying Xu, Yuhang Wu, Dongsheng Guo, Ge Gao, Keyu Lai, Fan Yang, Kepin Wang, Han Wu, Liangxue Lai, Jialiang Li, Kecheng Xu, Yin-xiong Li
Generation of two H1 hESC sublines carrying a heterozygous and homozygous knock-out of RB1
2017-07-11 00:00:00.0 11th Jul 2017Journal etc.
DOI: 10.1016/j.scr.2017.07.005Associated cell lines:
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Federico González-Pozas, Rosa Montes, Joan Domingo-Reinés, Verónica Ayllón, Verónica Ramos-Mejía
Establishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4
2017-07-10 00:00:00.0 10th Jul 2017Journal etc.
DOI: 10.1016/j.scr.2017.07.008Associated cell lines:
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Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J. Kim, David A. Brafman
Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi003-A) and non-demented control (ASUi004-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant
2017-07-10 00:00:00.0 10th Jul 2017Journal etc.
DOI: 10.1016/j.scr.2017.07.003 -
Lukovic D
Generation of a human iPSC line from a patient with retinitis pigmentosa caused by mutation in PRPF8 gene.
2017-07-06 10:43:11.0 6th Jul 2017Journal etc.
PubMed: 28677533 DOI: 10.1016/j.scr.2017.03.007Associated cell lines:
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Wongkummool W
Derivation of the human induced pluripotent stem cell line MUi017-A from a patient with homozygous Hemoglobin Constant Spring.
2017-07-06 10:42:29.0 6th Jul 2017Journal etc.
PubMed: 28395746 DOI: 10.1016/j.scr.2017.02.014Associated cell lines:
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Tangprasittipap A
Generation of induced pluripotent stem cells from peripheral blood CD34+ hematopoietic progenitors of a 31year old healthy woman.
2017-07-06 10:41:55.0 6th Jul 2017Journal etc.
PubMed: 28395748 DOI: 10.1016/j.scr.2017.02.013Associated cell lines:
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Lach MS
A feeder- and xeno-free human induced pluripotent stem cell line obtained from primary human dermal fibroblasts with epigenetic repression of reprogramming factors expression: GPCCi001-A.
2017-07-06 10:40:59.0 6th Jul 2017Journal etc.
PubMed: 28395738 DOI: 10.1016/j.scr.2017.02.004Associated cell lines:
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Yingying Xu
Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9
2017-07-06 10:12:11.0 6th Jul 2017Journal etc.
PubMed: DOI: 10.1016/j.scr.2017.05.006Associated cell lines:
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De Sousa PA
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.
2017-07-06 10:09:27.0 6th Jul 2017Journal etc.
PubMed: 28334554 DOI: 10.1016/j.scr.2017.03.002Associated cell lines:
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Wongkummool W
Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2.
2017-07-06 10:06:42.0 6th Jul 2017Journal etc.
PubMed: 28395745 DOI: 10.1016/j.scr.2017.02.012Associated cell lines:
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Nimsanor N
Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia.
2017-07-06 09:49:24.0 6th Jul 2017Journal etc.
PubMed: 27789411 DOI: 10.1016/j.scr.2016.10.006Associated cell lines:
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Nimsanor N
Generation of an isogenic, gene-corrected iPSC line from a pre-symptomatic 28-year-old woman with an R406W mutation in the microtubule associated protein tau (MAPT) gene.
2017-07-06 09:48:57.0 6th Jul 2017Journal etc.
PubMed: 27934590 DOI: 10.1016/j.scr.2016.09.024Associated cell lines:
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Nimsanor N
Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene.
2017-07-06 09:48:27.0 6th Jul 2017Journal etc.
PubMed: 27789409 DOI: 10.1016/j.scr.2016.09.021Associated cell lines:
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Nimsanor N
Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene.
2017-07-06 09:46:30.0 6th Jul 2017Journal etc.
PubMed: 27934586 DOI: 10.1016/j.scr.2016.09.020Associated cell lines:
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Nimsanor N
Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases.
2017-07-06 09:45:36.0 6th Jul 2017Journal etc.
PubMed: 27789407 DOI: 10.1016/j.scr.2016.09.019Associated cell lines:
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Skrzypczyk A
Generation of induced pluripotent stem cell line from foreskin fibroblasts.
2017-07-06 09:44:55.0 6th Jul 2017Journal etc.
PubMed: 27789413 DOI: 10.1016/j.scr.2016.09.014Associated cell lines:
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Hansen SK
Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3.
2017-07-06 09:42:45.0 6th Jul 2017Journal etc.
PubMed: 27596958 DOI: 10.1016/j.scr.2016.07.004Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe013-A (RC-9).
2017-07-06 09:42:02.0 6th Jul 2017Journal etc.
PubMed: 27558601 DOI: 10.1016/j.scr.2016.04.020Associated cell lines:
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Hansen SK
Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11.
2017-07-06 09:41:12.0 6th Jul 2017Journal etc.
PubMed: 27346191 DOI: 10.1016/j.scr.2016.02.042Associated cell lines:
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Hansen SK
Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11.
2017-07-06 09:40:48.0 6th Jul 2017Journal etc.
PubMed: 27346190 DOI: 10.1016/j.scr.2016.02.040Associated cell lines:
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Rossbach B
Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using integration free Sendai virus technology.
2017-07-06 09:34:37.0 6th Jul 2017Journal etc.
PubMed: 28677531 DOI: 10.1016/j.scr.2016.09.002Associated cell lines:
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Tubsuwan A
Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1.
2017-07-06 09:30:07.0 6th Jul 2017Journal etc.
PubMed: 27345792 DOI: 10.1016/j.scr.2015.12.015Associated cell lines:
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Rasmussen MA
Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.
2017-07-06 09:29:15.0 6th Jul 2017Journal etc.
PubMed: 27345791 DOI: 10.1016/j.scr.2015.12.012Associated cell lines:
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Rasmussen MA
Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT).
2017-07-06 09:24:33.0 6th Jul 2017Journal etc.
PubMed: 27345788 DOI: 10.1016/j.scr.2015.12.008Associated cell lines:
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Rasmussen MA
Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT).
2017-07-06 09:23:39.0 6th Jul 2017Journal etc.
PubMed: 27345789 DOI: 10.1016/j.scr.2015.12.006Associated cell lines:
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Hildebrand L
Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples.
2017-07-06 09:23:07.0 6th Jul 2017Journal etc.
PubMed: 27345784 DOI: 10.1016/j.scr.2015.11.017Associated cell lines:
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Singh H
Up-scaling single cell-inoculated suspension culture of human embryonic stem cells.
2017-07-06 09:22:21.0 6th Jul 2017Journal etc.
PubMed: 20363202 DOI: 10.1016/j.scr.2010.03.001Associated cell lines:
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Yanli Liu, Feima Wu, Yuanqi Zhuang, Dongsheng Guo, Nasir Abbas, Ruzi Wei, Kepin Wang, Yan Chen, Jiawang Tao, Yuhang Wu, Fang Yuan, Tingcai Pan, Fan Yang, Keyu Lai, Liangxue Lai, Yin-xiong Li
Generation of two MEN1 knockout lines from a human embryonic stem cell line
2017-06-10 00:00:00.0 10th Jun 2017Journal etc.
DOI: 10.1016/j.scr.2017.06.005Associated cell lines:
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Yanli Liu, Feima Wu, Yuanqi Zhuang, Dongsheng Guo, Nasir Abbas, Ruzi Wei, Kepin Wang, Yan Chen, Jiawang Tao, Yuhang Wu, Fang Yuan, Tingcai Pan, Fan Yang, Keyu Lai, Liangxue Lai, Yin-xiong Li
Generation of three miR-122 knockout lines from a human embryonic stem cell line
2017-06-09 00:00:00.0 9th Jun 2017Journal etc.
DOI: 10.1016/j.scr.2017.06.004Associated cell lines:
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Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J. Kim, David A. Brafman
Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi001-A) and non-demented control (ASUi002-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant
2017-06-08 00:00:00.0 8th Jun 2017Journal etc.
DOI: 10.1016/j.scr.2017.06.003 -
L. Miquel-Serra, A. Duarri, Y. Muñoz, B. Kuebler, B. Aran, C. Costa, M. Martí, M. Comabella, S. Malhotra, X. Montalban, A. Veiga, A. Raya
Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines
2017-06-07 00:00:00.0 7th Jun 2017Journal etc.
DOI: 10.1016/j.scr.2017.06.001 -
Ye J.
High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos
2017-06-05 00:00:00.0 5th Jun 2017Journal etc.
DOI: 10.1186/s13287-017-0561-yAssociated cell lines:
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Alexandra Haase
Generation of non-transgenic iPS cells from human cord blood CD34+ cells under animal component-free conditions
2017-05-10 13:56:29.0 10th May 2017Journal etc.
PubMed: DOI: 10.1016/j.scr.2017.03.022Associated cell lines:
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Kyung-Ok Uhm
Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system
2017-05-10 13:40:36.0 10th May 2017Journal etc.
PubMed: DOI: 10.1016/j.scr.2017.03.019Associated cell lines:
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Kyung-Ok Uhm
Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a non-integration system
2017-05-10 13:39:45.0 10th May 2017Journal etc.
PubMed: DOI: 10.1016/j.scr.2017.03.009Associated cell lines:
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Kyung-Ok Uhm
Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system
2017-05-10 13:38:05.0 10th May 2017Journal etc.
PubMed: DOI: 10.1016/j.scr.2017.02.009Associated cell lines:
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De Sousa PA
Development and production of good manufacturing practice grade human embryonic stem cell lines as source material for clinical application.
2017-05-10 13:34:58.0 10th May 2017Journal etc.
PubMed: 27639108 DOI: 10.1016/j.scr.2016.08.011 -
De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe015-A (RC-11).
2017-05-10 13:31:34.0 10th May 2017Journal etc.
PubMed: 27558602 DOI: 10.1016/j.scr.2016.04.021Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe021-A (RC-17).
2017-05-10 13:28:36.0 10th May 2017Journal etc.
PubMed: 27558596 DOI: 10.1016/j.scr.2016.04.019Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe017-A (RC-13).
2017-05-10 13:28:09.0 10th May 2017Journal etc.
PubMed: 27346201 DOI: 10.1016/j.scr.2016.04.006Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe018-A (RC-14).
2017-05-10 13:27:31.0 10th May 2017Journal etc.
PubMed: 27346202 DOI: 10.1016/j.scr.2016.04.004Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe019-A (RC-15).
2017-05-10 13:26:51.0 10th May 2017Journal etc.
PubMed: 27346200 DOI: 10.1016/j.scr.2016.04.003Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe020-a (RC-16).
2017-05-10 13:26:08.0 10th May 2017Journal etc.
PubMed: 27346205 DOI: 10.1016/j.scr.2016.04.002Associated cell lines:
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De Sousa PA
Derivation of the clinical grade human embryonic stem cell line RCe016-A (RC-12).
2017-05-10 13:25:34.0 10th May 2017Journal etc.
PubMed: 27346204 DOI: 10.1016/j.scr.2016.04.001Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe007-A (RC-3).
2017-05-10 11:51:15.0 10th May 2017Journal etc.
PubMed: 27346192 DOI: 10.1016/j.scr.2016.02.041Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe008-A (RC-4).
2017-05-10 11:50:35.0 10th May 2017Journal etc.
PubMed: 27346193 DOI: 10.1016/j.scr.2016.02.039Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe011-A (RC-7).
2017-05-10 11:49:50.0 10th May 2017Journal etc.
PubMed: 27346020 DOI: 10.1016/j.scr.2016.02.036Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe010-A (RC-6).
2017-05-10 11:48:48.0 10th May 2017Journal etc.
PubMed: 27346019 DOI: 10.1016/j.scr.2016.02.035Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe014-A (RC-10).
2017-05-10 11:48:09.0 10th May 2017Journal etc.
PubMed: 27346029 DOI: 10.1016/j.scr.2016.02.034Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe012-A (RC-8).
2017-05-10 11:47:38.0 10th May 2017Journal etc.
PubMed: 27346021 DOI: 10.1016/j.scr.2016.02.033Associated cell lines:
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De Sousa PA
Derivation of the human embryonic stem cell line RCe009-A (RC-5).
2017-05-10 11:46:34.0 10th May 2017Journal etc.
PubMed: 27346004 DOI: 10.1016/j.scr.2016.02.030 -
De Sousa PA
Derivation of the human embryonic stem cell line RCe006-A (RC-2).
2017-05-10 11:45:38.0 10th May 2017Journal etc.
PubMed: 27346014 DOI: 10.1016/j.scr.2016.02.029Associated cell lines:
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Fatima A
Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.
2017-05-10 10:56:28.0 10th May 2017Journal etc.
PubMed: 27345990 DOI: 10.1016/j.scr.2015.12.039Associated cell lines:
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Rossbach B
Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using an integration free vector.
2017-05-10 10:49:45.0 10th May 2017Journal etc.
PubMed: 27345993 DOI: 10.1016/j.scr.2015.12.018Associated cell lines:
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Buonocore F, Kühnen P, Suntharalingham JP, Del Valle I, Digweed M, Stachelscheid H, Khajavi N, Didi M, Brady AF, Blankenstein O, Procter AM, Dimitri P, Wales JKH, Ghirri P, Knöbl D, Strahm B, Erlacher M, Wlodarski MW, Chen W, Kokai GK, Anderson G, Morrogh D, Moulding DA, McKee SA, Niemeyer CM, Grüters A, Achermann JC.
Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
2017-03-27 00:00:00.0 27th Mar 2017Journal etc.
PubMed: 28346228 DOI: 10.1172/jci91913 -
Xu C, Zhang Y, Wang Q, Xu Z, Jiang J, Gao Y, Gao M, Kang J, Wu M, Xiong J, Ji K, Yuan W, Wang Y, Liu H.
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling.
2016-11-04 00:00:00.0 4th Nov 2016Journal etc.
PubMed: 27811843 DOI: 10.1038/ncomms13287Associated cell lines:
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Hossini AM, Quast AS, Plötz M, Grauel K, Exner T, Küchler J, Stachelscheid H, Eberle J, Rabien A, Makrantonaki E, Zouboulis CC.
PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells.
2016-05-03 00:00:00.0 3rd May 2016Journal etc.
PubMed: 27138223 DOI: 10.1371/journal.pone.0154770 -
Adamo A
7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages.
2016-02-10 00:00:00.0 10th Feb 2016Journal etc.
PubMed: 25501393 DOI: 10.1038/ng.3169 -
Lim ML
Decellularized feeders: an optimized method for culturing pluripotent cells.
2016-02-10 00:00:00.0 10th Feb 2016Journal etc.
PubMed: 24167316 DOI: 10.5966/sctm.2013-0077Associated cell lines:
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Bella Rossbach, Laura Hildebrand, Linda El-Ahmad, Harald Stachelscheid, Petra Reinke, Andreas Kurtz
WITHDRAWN: Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using integration free Sendai technology
2016-01-01 00:00:00.0 1st Jan 2016Journal etc.
DOI: 10.1016/j.scr.2015.12.021Associated cell lines:
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Jenny
Preimplantation Genetic Screening
2015-04-15 00:00:00.0 15th Apr 2015Journal etc.
PubMed:Associated cell lines:
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Shao K
Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 23032973 DOI: 10.1038/mt.2012.207Associated cell lines:
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Fatima A
The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 24349418 DOI: 10.1371/journal.pone.0083005 -
Koch CM
Pluripotent stem cells escape from senescence-associated DNA methylation changes.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 23080539 DOI: 10.1101/gr.141945.112Associated cell lines:
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Zhang XH
Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 23684427 DOI: 10.1016/j.ceca.2013.04.004 -
Fatima A
In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 22178870 DOI: 10.1159/000335753 -
Frobel J
Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells.
2015-03-11 00:00:00.0 11th Mar 2015Journal etc.
PubMed: 25241740 DOI: 10.1016/j.stemcr.2014.07.003Associated cell lines:
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Desmarais JA
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.
2015-01-22 00:00:00.0 22nd Jan 2015Journal etc.
PubMed: 26810087 DOI: 10.1186/s13287-016-0279-2 -
Dr. Anna Veiga
Reprogramming of human fibroblasts to induce pluripotent stem cells under xeno-free conditions
2010-09-09 00:00:00.0 9th Sep 2010Journal etc.
PubMed: 19890879 DOI: 10.1002/stem.248Abstract:
The availability of induced pluripotent stem cells (iPSCs) has created extraordinary opportunities for modeling and perhaps treating human disease. However, all reprogramming protocols used to date involve the use of products of animal origin. Here, … Show all
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Steven Shoei-Lung Li
Identification of microRNAs regulated by activin A in human embryonic stem cells.
2010-03-10 00:00:00.0 10th Mar 2010Journal etc.
PubMed: 19885849 DOI: 10.1002/jcb.22385Abstract:
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells … Show all
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Dr. Anna Veiga
Desease corrected haematopoietic progenitors from Fanconi anemia induced pluripotent stem cells
2010-02-22 00:00:00.0 22nd Feb 2010Journal etc.
PubMed: 19483674 DOI: 10.1038/nature08129Abstract:
The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific pluripotent cells and provided valuable experimental platforms to model human disease. Patient-specific iPS cells are also thought to hold great the… Show all
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Prof. Petr Dvorak
Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes
2010-02-17 00:00:00.0 17th Feb 2010Journal etc.
PubMed: 20016957 DOI: 10.1007/s12015-009-9085-xAbstract:
In just a few years hundreds of human embryonic stem cell (hESC) lines have been established in laboratories around the world and many programmes of research initiated to investigate their properties and broad ranging potential in therapy and for oth… Show all
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Prof. Petr Dvorak
Lack of Population Diversity in Human Embryonic Stem-Cell Lines
2010-02-17 00:00:00.0 17th Feb 2010Journal etc.
PubMed: 20018958 DOI: 10.1056/NEJMc0910371Abstract:
We determined the genetic ancestry of a large collection of stem-cell lines. We have found that widely distributed stem-cell lines lack population diversity and that none of these lines derive from populations with recent African ancestry. Efforts t… Show all
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Prof. Dr. Marisa Jaconi
Derivation of human embryonic stem cell lines from single cells of 4-cell stage embryos: be aware of the risks.
2010-02-16 00:00:00.0 16th Feb 2010Journal etc.
PubMed: 18854403 DOI: 10.1093/humrep/den369Associated cell lines:
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Prof. Dr. Outi Hovatta
Cryopreservation of dissociated human embryonic stem cells in the presence of ROCK inhibitor
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19585460 DOI: 10.1002/9780470151808.sc01c08s10Abstract:
Two different methods have been adopted for the cryopreservation of human embryonic stem cells (hESCs): vitrification and conventional slow freezing/rapid thawing. However, these methods present poor viability and high differentiation rates. Therefor… Show all
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Prof. Dr. Outi Hovatta
Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart.
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 18467659 DOI: 10.1634/stemcells.2008.0111Abstract:
In order to study the ability of costimulation blockade to induce tolerance to human embryonic stem cells (HESC), severe combined immunodeficient (SCID), and immunocompetent C57BL/6 mice treated with costimulation blockade received intratesticular an… Show all
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Prof. Dr. Outi Hovatta
transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19175403 DOI: 10.1111/j.1460-9568.2008.06599.xAbstract:
Cortical stem cell transplantation may help replace lost brain cells after stroke and improve the functional outcome. In this study, we transplanted human embryonic stem cell (hESC)-derived neural precursor cells (hNPCs) or vehicle into the cortex of… Show all
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Prof. Dr. Outi Hovatta
CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19383417 DOI: 10.1016/j.scr.2008.08.001Abstract:
Human embryonic stem cells (hESCs) are pluripotent cells that can differentiate into neural cell lineages. These neural populations are usually heterogeneous and can contain undifferentiated pluripotent cells that are capable of producing teratomas i… Show all
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Prof. Dr. Outi Hovatta
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19383789 DOI: 10.1073/pnas.0902396106Abstract:
Signaling factors involved in CNS development have been used to control the differentiation of embryonic stem cells (ESCs) into mesencephalic dopamine (mesDA) neurons, but tend to generate a limited yield of desired cell type. Here we show that force… Show all
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Prof. Dr. Outi Hovatta
A gene expression signature shared by human mature oocytes and embryonic stem cells
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19128516 DOI: 10.1186/1471-2164-10-10Abstract:
BACKGROUND: The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have far reaching implication for in vitro fertilization and regenerati… Show all
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Prof. Dr. Outi Hovatta
Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell derived neurons
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19799651 DOI: 10.1111/j.1582-4934.2009.00916.xAbstract:
Cholinergic neurotransmission is essential for many important functions in the brain, including cognitive mechanisms. Here we demonstrate that human embryonic stem (hES) cells differentiate into a population of neuronal cells that express the choline… Show all
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Prof. Dr. Outi Hovatta
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells
2010-02-15 00:00:00.0 15th Feb 2010Journal etc.
PubMed: 19796621 DOI: 10.1016/j.stem.2009.08.019Abstract:
Control over progenitor proliferation and neurogenesis remains a key challenge for stem cell neurobiology and a prerequisite for successful stem cell replacement therapies for neurodegenerative diseases like Parkinson's disease (PD). Here, we examine… Show all
Associated cell lines:
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Camarasa MV
Derivation of Man-1 and Man-2 research grade human embryonic stem cell lines
2010-02-14 00:00:00.0 14th Feb 2010Journal etc.
PubMed: 20177994 DOI: 10.1007/s11626-010-9291-5Abstract:
We report here the derivation of two new human embryonic stem cell lines, Man-1 and Man-2, and their full characterization as novel pluripotent stem cell lines. Man-1 was derived from an embryo surplus to requirement from routine IVF, while Man-2 was… Show all
Associated cell lines:
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Prof. Norio Nakatsuji
Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage.
2010-02-11 00:00:00.0 11th Feb 2010Journal etc.
PubMed: 16707099 DOI: 10.1016/j.bbrc.2006.04.135Abstract:
Human ES (hES) cell lines are considered to be a valuable resource for medical research and for applications in cell therapy and drug discovery. For such utilization of hES cells to be realized, however, protocols involved in the use of hES cells, su… Show all
Associated cell lines:
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Prof. Petr Dvorak
A complex role for FGF-2 in self renewal, survival, and adhesion of human embryonic stem cells
2010-02-10 00:00:00.0 10th Feb 2010Journal etc.
PubMed: 19544431 DOI: 10.1002/stem.128Abstract:
The transcription program that is responsible for the pluripotency of human ESCs (hESCs) is believed to be comaintained by exogenous fibroblast growth factor-2 (FGF-2), which activates FGF receptors (FGFRs) and stimulates the mitogen-activated protei… Show all
Associated cell lines:
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Prof. Petr Dvorak
Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin
2010-02-10 00:00:00.0 10th Feb 2010Journal etc.
PubMed: 19401887 DOI: 10.1080/14653240802595531Abstract:
Microvesicles (MVs) shed from the plasma membrane of eukaryotic cells including human embryonic stem cells (hESCs) contain proteins, lipids, and RNAs and serve as mediators of cell-to-cell communication. However, they may also contain immunogenic mem… Show all
Associated cell lines:
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Xiaofang Sun
Similar biological characteristics of human embryonic stem cell lines with normal and abnormal karyotypes.
2010-02-09 00:00:00.0 9th Feb 2010Journal etc.
PubMed: 18611919 DOI: 10.1093/humrep/den137Abstract:
BACKGROUND: Human embryonic stem cell (hESC) lines derived from poor quality embryos usually have either normal or abnormal karyotypes. However, it is still unclear whether their biological characteristics are similar. METHODS: Seven new hESC lines w… Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells
2009-06-29 00:00:00.0 29th Jun 2009Journal etc.
PubMed: 19556288 DOI: 10.1093/humrep/dep232Abstract:
BACKGROUND Feeder cells are frequently used for the early-stage of derivation and culture of human embryonic stem cell (hESC) lines. METHODS We established a conditionally immortalized human foreskin fibroblast line that secreted basic fibroblast gro… Show all
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Hui Z. Sheng
Human embryonic stem cell lines derived from the Chinese population
2009-02-24 00:00:00.0 24th Feb 2009Journal etc.
PubMed: 15916726 DOI: 10.1038/sj.cr.7290307Abstract:
Six human embryonic stem cell lines were established from surplus blastocysts. The cell lines expressed alkaline phosphatase and molecules typical of primate embryonic stem cells, including Oct-4, Nanog, TDGF1, Sox2, EBAF, Thy-1, FGF4, Rex-1, SSEA-3,… Show all
Associated cell lines:
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Dr. Claus Yding Andersen
Human Embryonic Stem Cells in Culture Possess Primary Cilia
2009-02-23 00:00:00.0 23rd Feb 2009Journal etc.
PubMed: 18332216 DOI: 10.1083/jcb.200706028Abstract:
Human embryonic stem cells (hESCs) are potential therapeutic tools and models of human development. With a growing interest in primary cilia in signal transduction pathways that are crucial for embryological development and tissue differentiation and… Show all
Associated cell lines:
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Dr. Anna Veiga
Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor quality blastocysts
2008-12-22 00:00:00.0 22nd Dec 2008Journal etc.
PubMed: 19028986 DOI: 10.1101/sbq.2008.73.038Abstract:
Human embryonic stem (hES) cells represent a potential source for cell replacement therapy of many degenerative diseases. Most frequently, hES cell lines are derived from surplus embryos from assisted reproduction cycles, independent of their quality… Show all
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Dr. Anna Veiga
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
2008-12-22 00:00:00.0 22nd Dec 2008Journal etc.
PubMed: 18931654 DOI: 10.1038/nbt.1503Abstract:
The utility of induced pluripotent stem (iPS) cells for investigating the molecular logic of pluripotency and for eventual clinical application is limited by the low efficiency of current methods for reprogramming. Here we show that reprogramming of … Show all
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Prof. Dr. Lorraine Young
Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification.
2008-12-04 00:00:00.0 4th Dec 2008Journal etc.
PubMed: 18772870 DOI: 10.1038/nprot.2008.140Abstract:
Realizing the potential of human embryonic stem cells (hESCs) in research and commercial applications requires generic protocols for culture, expansion and genetic modification that function between multiple lines. Here we describe a feeder-free hESC… Show all
Associated cell lines:
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Prof. Dr. Lorraine Young
Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability.
2008-12-04 00:00:00.0 4th Dec 2008Journal etc.
PubMed: 17185609 DOI: 10.1634/stemcells.2006-0598Abstract:
Although all human ESC (hESC) lines have similar morphology, express key pluripotency markers, and can differentiate toward primitive germ layers in vitro, the lineage-specific developmental potential may vary between individual lines. In the current… Show all
Associated cell lines:
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Prof. Dr. Lorraine Young
Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines
2008-12-04 00:00:00.0 4th Dec 2008Journal etc.
PubMed: 17989250 DOI: 10.1101/gr.6609207Abstract:
Disregulation of imprinted genes can be associated with tumorigenesis and altered cell differentiation capacity and so could provide adverse outcomes for stem cell applications. Although the maintenance of mouse and primate embryonic stem cells in a … Show all
Associated cell lines:
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Allegrucci C
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome.
2008-12-04 00:00:00.0 4th Dec 2008Journal etc.
PubMed: 17409196 DOI: 10.1093/hmg/ddm074Abstract:
Widespread provision of human embryonic stem cells (hESCs) for therapeutic use, drug screening and disease modelling will require cell lines sustainable over long periods in culture. Since the short-term, in vitro culture of mammalian embryos can res… Show all
Associated cell lines:
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Prof. Dr. Bernie Tuch
Derivation of three clones from human embryonic stem cell lines by FACS sorting and their characterization.
2008-11-04 00:00:00.0 4th Nov 2008Journal etc.
PubMed: 16522163 DOI: 10.1089/scd.2006.15.61Abstract:
Here we describe the first report of three human embryonic stem cell (hESC) clones, hES 3.1, 3.2, and 3.3, derived from the parent line hES3 by sorting of single-cell preparations by flow cytometry. The viability of single-cell preparations before an… Show all
Associated cell lines:
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Dr. Carlos Simón Valles
Derivation and characterization of three new Spanish human embryonic stem cell lines (VAL -3 -4 -5) on human feeder and in serum-free conditions.
2008-11-04 00:00:00.0 4th Nov 2008Journal etc.
PubMed: 17169214Abstract:
A total of 184 human embryos, frozen for >5 years, were donated; informed consent was obtained according to Spanish law 45/2003. Survival rate was 40% and three out of 24 blastocysts (12.5%) developed into putative hESC lines, named VAL-3, VAL-4, … Show all
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Andy Peng Xiang
Establishment and characterization of two new human embryonic stem cell lines, SYSU-1 and SYSU-2.
2008-11-04 00:00:00.0 4th Nov 2008Journal etc.
PubMed: 17442208Abstract:
Human embryonic stem cells can propagate indefinitely in vitro and are able to differentiate into derivatives of all three embryonic germ layers. The excitement surrounding human embryonic stem cells lies largely in their potential to produce special… Show all
Associated cell lines:
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Chavez SL
Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditions.
2008-10-31 00:00:00.0 31st Oct 2008Journal etc.
PubMed: 18513167 DOI: 10.1089/scd.2007.0216Abstract:
Human embryonic stem cells (hESCs) provide a renewable source of a variety of cell types with the potential for use in both scientific research and clinical cell-based therapy. Several hESC lines have previously been isolated and characterized, howev… Show all
Associated cell lines:
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Prof. Dr. James A. Thompson
Derivation of human embryonic stem cells in defined conditions.
2008-10-31 00:00:00.0 31st Oct 2008Journal etc.
PubMed: 16388305 DOI: 10.1038/nbt1177Abstract:
We have previously reported that high concentrations of basic fibroblast growth factor (bFGF) support feeder-independent growth of human embryonic stem (ES) cells, but those conditions included poorly defined serum and matrix components. Here we repo… Show all
Associated cell lines:
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Dr. Derek Hei
Embryonic stem cell lines derived from human blastocysts
2008-10-13 00:00:00.0 13th Oct 2008Journal etc.
PubMed: 9804556Abstract:
Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other earl… Show all
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Dr. Hossein Baharvand
Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst
2008-10-13 00:00:00.0 13th Oct 2008Journal etc.
PubMed: 15270778 DOI: 10.1111/j.1432-0436.2004.07205005.xAbstract:
Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in… Show all
Associated cell lines:
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Shinya Yamanaka
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
2008-10-13 00:00:00.0 13th Oct 2008Journal etc.
PubMed: 18035408 DOI: 10.1016/j.cell.2007.11.019Abstract:
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline t… Show all
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Prof. Dr. Bernie Tuch
Derivation of a new human embryonic stem cell line, endeavour-1, and its clonal propagation
2008-10-13 00:00:00.0 13th Oct 2008Journal etc.
PubMed: 18271699 DOI: 10.1089/scd.2007.0055Abstract:
Here we describe the derivation of a novel human embryonic stem (hES) cell line, Endeavour-1 (E1), its four new clonal lines (E1C1, E1C2, E1C3, E1C4), and their characterization. E1 and its clonal lines are propagated on human fetal fibroblasts (HFFs… Show all
Associated cell lines:
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Dr. Allan Robins
Humanic Embryonic Stem Cell Lines Derived from Discarded Embryos
2008-10-13 00:00:00.0 13th Oct 2008Journal etc.
PubMed: 12968106 DOI: 10.1634/stemcells.21-5-521Abstract:
Human pluripotent embryonic stem (ES) cells have important potential in regenerative medicine and as models for human preimplantation development; however, debate continues over whether embryos should be destroyed to produce human ES cells. We have d… Show all
Associated cell lines:
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Dr. Hossein Baharvand
Generation of new human embryonic stem cell lines with diploid and triploid karyotypes.
2008-10-07 00:00:00.0 7th Oct 2008Journal etc.
PubMed: 16512855 DOI: 10.1111/j.1440-169x.2006.00851.xAbstract:
Human pluripotent embryonic stem cells (hESC) have great promise for research into human developmental biology and the development of cell therapies for the treatment of diseases. To meet the increased demand for characterized hESC lines, we presen… Show all
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Prof. Christine Mummery
Insulin Redirects Differentiation from Cardiogenic Mesoderm and Endoderm to Neuroectoderm in Differentiating Human Embryonic Stem Cells
2008-09-29 00:00:00.0 29th Sep 2008Journal etc.
PubMed: 18096723 DOI: 10.1634/stemcells.2007-0617Abstract:
Human embryonic stem cells (hESC) can proliferate indefinitely while retaining the capacity to form derivatives of all three germ layers. We have reported previously that hESC differentiate into cardiomyocytes when cocultured with a visceral endoderm… Show all
Associated cell lines:
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Prof. Christine Mummery
Human embryonic stem cells: towards therapies for cardiac disease. Derivation of a Dutch human embryonic stem cell line
2008-09-29 00:00:00.0 29th Sep 2008Journal etc.
PubMed: 16274613Abstract:
Cell transplantation is being discussed as a potential therapy for multiple disorders caused by loss or malfunction of single or at most a few cell types. These include diabetes, Parkinson·s disease and myocardial infarction or cardiac failur… Show all
Associated cell lines:
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Prof. Christine Mummery
Improved genetic manipulation of human embryonic stem cells
2008-09-29 00:00:00.0 29th Sep 2008Journal etc.
PubMed: 18391958 DOI: 10.1038/NMETH.1200Abstract:
Low efficiency of transfection limits the ability to genetically manipulate human embryonic stem cells (hESCs), and differences in cell derivation and culture methods require optimization of transfection protocols. We transiently transferred multiple… Show all
Associated cell lines:
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Prof. Dr, Karen Sermon
Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions.
2008-09-22 00:00:00.0 22nd Sep 2008Journal etc.
PubMed: 17090644 DOI: 10.1093/molehr/gal091Abstract:
Feeder-free human embryonic stem cell (hESC) culture is associated with the presence of mesenchymal-like cells appearing at the periphery of the colonies. The aim of this study was to identify this early differentiation process. Long-term feeder-free… Show all
Associated cell lines:
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Prof. Dr, Karen Sermon
Efficient differentiation of human embryonic stem cells into a homogeneous population of osteoprogenitor-like cells.
2008-09-22 00:00:00.0 22nd Sep 2008Journal etc.
PubMed: 18492382Abstract:
The use of human embryonic stem cells (hESC) in both research and therapeutic applications requires relatively large homogeneous populations of differentiated cells. The differentiation of three hESC lines into highly homogeneous populations of osteo… Show all
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Prof. Dr, Karen Sermon
GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions.
2008-09-22 00:00:00.0 22nd Sep 2008Journal etc.
PubMed: 18263607 DOI: 10.1093/molehr/gan001Abstract:
Feeder-free culture induces spontaneous differentiation of human embryonic stem cells (hESCs), identified as an epithelial to mesenchymal transition (EMT). The maintenance of pluripotency of hESCs in feeder-free cultures through the activation of the… Show all
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Prof. Dr, Karen Sermon
CTG repeat instability in a human embryonic stem cell line carrying the myotonic dystrophy type 1 mutation.
2008-09-22 00:00:00.0 22nd Sep 2008Journal etc.
PubMed: 18577525 DOI: 10.1093/molehr/gan034Abstract:
Human embryonic stem cells (hESC) are considered to be an indefinite source of self-renewing cells that can differentiate into all types of cells of the human body and could be used in regenerative medicine, drug discovery and as a model for studying… Show all
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Prof. Dr. Marisa Jaconi
Derivation of the first Swiss human embryonic stem cell line from a single blastomere of an arrested four-cell stage embryo
2008-09-18 00:00:00.0 18th Sep 2008Journal etc.
PubMed: 18803035 DOI: 2008/37/smw-12385Abstract:
Summary Principles: Human embryonic stem cells (hESC) hold huge potential for regenerative medicine. So far, the majority of hESC lines have been derived from the isolated inner cell mass (ICM) of blastocysts of variable quality, and several of the… Show all
Associated cell lines:
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Dr. Stephen Minger
Generation of a human embryonic stem cell line encoding the cystic fibrosis mutation F508, using preimplantaion genetic diagnosis
2008-08-19 00:00:00.0 19th Aug 2008Journal etc.
PubMed: 15820050Abstract:
Human embryonic stem (hES) cells are pluripotent cells isolated from early human embryos. They can be grown in vitro and made to differentiate into many different cell types. These properties have suggested that they may be useful in cell replacement… Show all
Associated cell lines:
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Dr. Allan Robins
A variant human embryonic stem cell line exhibits rapid growth after passaging and reliable dopaminergic differentiation
2008-08-08 00:00:00.0 8th Aug 2008Journal etc.
PubMed: 15798361Abstract:
Purpose: To explore a karyotypically abnormal variant human embryonic stem cell (hESC) line, BG01V, as a potential model for studies of dopaminergic neuronal differentiation. Methods: The properties of BG01V cells were compared to those of normal … Show all
Associated cell lines:
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Prof. Dr. Benjamin Reubinoff
Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis.
2008-08-04 00:00:00.0 4th Aug 2008Journal etc.
PubMed: 17989069 DOI: 10.1093/humrep/dem351Abstract:
BACKGROUND: Human embryonic stem cells (hESCs) suitable for future transplantation therapy should preferably be developed in an animal-free system. Our objective was to develop a laser-based system for the isolation of the inner cell mass (ICM) that … Show all
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M.Sc Zafer Nihat Candan
Establishment and characterization of new human embryonic stem cell lines
2008-05-18 00:00:00.0 18th May 2008Journal etc.
PubMed: 15949219Abstract:
Human embryonic stem cells (hESC), with their ability to differentiate into all cell types in the human body, are likely to play a very important therapeutic role in a variety of neurodegenerative and life-threatening disorders in the near future. Al… Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Monitoring and analysis of dynamic growth of human embryonic stem cells: comparison of automated instrumentation and conventional culturing methods.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17428350 DOI: 10.1186/1475-925X-6-11Abstract:
BACKGROUND: Human embryonic stem cells (hESCs) are a potential source of cells for use in regenerative medicine. Automation of culturing, monitoring and analysis is crucial for fast and reliable optimization of hESC culturing methods. Continuous moni… Show all
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Prof. Dr. Outi Hovatta
Mechanical isolation of the inner cell mass is effective in derivation of new human embryonic stem cell lines.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17959612 DOI: 10.1093/humrep/dem335Abstract:
BACKGROUND: For clinical grade human embryonic stem cell (hESC) lines, a robust derivation system without any substances having animal origin would be required. We have gradually improved our hESC derivations. Human skin fibroblasts were used as feed… Show all
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Prof. Dr. Outi Hovatta
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17572666 DOI: 10.1038/nbt1318Abstract:
The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression pat… Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Culture and expansion of the human embryonic stem cell line HS 181, evaluated in a double-colour system.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 15345126 DOI: 10.1089/scd.2004.13.337Abstract:
An approach of using RFP-transfected human foreskin fibroblasts (hFS-RFP) to support the growth of GFP expressing human embryonic stem cells (hES; HS181-GFP) is reported. The two-color system was applied to detect interactions between hFS and human e… Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17204602 DOI: 10.1634/stemcells.2006-0352Abstract:
Microarray technology provides a unique opportunity to examine gene expression patterns in human embryonic stem cells (hESCs). We performed a meta-analysis of 38 original studies reporting on the transcriptome of hESCs. We determined that 1,076 genes… Show all
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Prof. Dr. Outi Hovatta
Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 15790775 DOI: 10.1634/stemcells.2004-0201Abstract:
Derivation and culture of human embryonic stem cells (hESCs) without animal-derived material would be optimal for cell transplantation. We derived two new hES (HS293 and HS306) and 10 early cell lines using serum replacement (SR) medium instead of co… Show all
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Prof. Dr. Outi Hovatta
Gene expression signatures of seven individual human embryonic stem cell lines
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 16081666 DOI: 10.1634/stemcells.2004-0341Abstract:
Identification of molecular components that define a pluripotent human embryonic stem cell (hESC) provides the basis for understanding the molecular mechanisms regulating the maintenance of pluripotency and induction of differentiation. We compared t… Show all
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Prof. Dr. Outi Hovatta
Unique gene expression signature by human embryonic stem cells cultured under serum-free conditions correlates with their enhanced and prolonged growth in an undifferentiated stage
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 16100004 DOI: 10.1634/stemcells.2004-0189Abstract:
Understanding the interaction between human embryonic stem cells (hESCs) and their microenvironment is crucial for the propagation and the differentiation of hESCs for therapeutic applications. hESCs maintain their characteristics both in serum-conta… Show all
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Prof. Dr. Outi Hovatta
Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17126334 DOI: 10.1016/j.fertnstert.2006.07.1509Abstract:
OBJECTIVE: To identify genes that are expressed differently during final oocyte maturation and early embryonic development in humans. DESIGN: Comparison of gene expression profiles of human germinal vesicle oocytes (hGVO), human embryonic stem cells … Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 16949591 DOI: 10.1016/j.fertnstert.2005.12.081Abstract:
OBJECTIVE: To investigate gene expression profiles during the early spontaneous differentiation of human embryonic stem cells (hESCs), with particular emphasis on leukemia inhibitory factor (LIF)-induced pathways and the ultrastructural surface morph… Show all
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Prof. Dr. Outi Hovatta
In vitro neural differentiation of human embryonic stem cells
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 15601586Abstract:
Human embryonic stem (hES) cells are seen as a source of defined neural cell population for pharmaceutical screening or transplantation and can be conducted to differentiate in vitro to mature neurons [1]. hES cells from line HS 237T (Karolinska … Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Testing of nine different xeno-free culture media for human embryonic stem cell cultures.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17251355 DOI: 10.1093/humrep/del523Abstract:
BACKGROUND: Human embryonic stem cells (hESC) are excellent candidates for cell replacement therapies. However, currently used culture conditions contain animal-derived components that bear a risk of transmitting animal pathogens and incorporation of… Show all
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Prof. Dr. Outi Hovatta
A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 12832363Abstract:
BACKGROUND: Human embryonic stem (hES) cell lines were first cultured using fetal mouse fibroblasts as feeder cells. To avoid feeders and to reduce the amount of xeno-components, Matrigel- and laminin-coated dishes, and conditioned mouse feeder cell … Show all
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Prof. Dr. Outi Hovatta
Differential lipolytic regulation in human embryonic stem cell-derived adipocytes.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17426319 DOI: 10.1038/oby.2007.595Abstract:
OBJECTIVE: Human embryonic stem cells (hESCs) have raised great hopes for future clinical applications. Several groups have succeeded in differentiating hESCs into adipocytes, as determined by morphology, mRNA expression, and protein secretion. Howev… Show all
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Prof. Dr. Outi Hovatta
Cultures of human embryonic stem cells: serum replacement medium or serum-containing media and the effect of basic fibroblast growth factor
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 15353086Abstract:
Human embryonic stem (hES) cells have traditionally been cultured in medium containing fetal calf serum (FCS) and mouse fibroblasts as feeder cells. The use of animal derived materials carries a risk of transmitting animal pathogens, and they are not… Show all
Associated cell lines:
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Prof. Dr. Outi Hovatta
Comparative genomic hybridisation and karyptyping of human embryonic stem cells reveals the occurrence of an isodicentric X chromosome after long-term cultivation
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 15044603 DOI: 10.1093/molehr/gah051Abstract:
Human embryonic stem (hES) cells are important research tools in studies of the physiology of early tissue differentiation. In addition, prospects are high regarding the use of these cells for successful cell transplantation. However, one concern has… Show all
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Prof. Dr. Outi Hovatta
Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17152062 DOI: 10.1002/glia.20463Abstract:
The great potential of human embryonic stem (hES) cells offers the opportunity both for studying basic developmental processes in vitro as well as for drug screening, modeling diseases, or future cell therapy. Defining protocols for the generation of… Show all
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Prof. Dr. Outi Hovatta
Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings.
2008-02-20 00:00:00.0 20th Feb 2008Journal etc.
PubMed: 17169186Abstract:
Recent studies have suggested that human embryonic stem cells (HESC) are immune-privileged and may thereby circumvent rejection. The expression of immunologically active molecules was studied by DNA microarray analysis and by flow cytometry. HESC wer… Show all
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Prof. Dr. Marisa Jaconi
Fetal bovine serum enables cardiac differentiation of human embryonic stem cells.
2008-01-16 00:00:00.0 16th Jan 2008Journal etc.
PubMed: 17459089 DOI: 10.1111/j.1432-0436.2007.00174.xAbstract:
During development, cardiac commitment within the mesoderm requires endoderm-secreted factors. Differentiation of embryonic stem cells into the three germ layers in vitro recapitulates developmental processes and can be influenced by supplements adde… Show all
Associated cell lines:
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Prof. Dr. Marisa Jaconi
Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: combined molecular and functional approaches.
2008-01-16 00:00:00.0 16th Jan 2008Journal etc.
PubMed: 17255522 DOI: 10.1634/stemcells.2006-0466Abstract:
Cardiomyocytes derived from human embryonic stem cells constitute a promising cell source for the regeneration of damaged hearts. The assessment of their in vitro functional properties is mandatory to envisage appropriate cardiac cell-based therapies… Show all
Associated cell lines:
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Dr. Johan Hyllner
Genomic alterations in cultured human embryonic stem cells
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 16142235 DOI: 10.1038/ng1631Abstract:
Cultured human embryonic stem cell (hESC) lines are an invaluable resource because they provide a uniform and stable genetic system for functional analyses and therapeutic applications. Nevertheless, these dividing cells, like other cells, probably u… Show all
Associated cell lines:
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Dr. Johan Hyllner
Facilitated expansion of human embryonic stem cells by single cell enzymatic dissociation
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 17379766 DOI: 10.1634/stemcells.2006-0607Abstract:
Traditionally, human embryonic stem cells (hESCs) are propagated by mechanical dissection or enzymatic dissociation into clusters of cells. To facilitate up-scaling and the use of hESC in various experimental manipulations, such as fluorescence-activ… Show all
Associated cell lines:
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Dr. Johan Hyllner
Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 17568565 DOI: 10.1016/j.bcp.2007.05.009Abstract:
Human embryonic stem cells (hESC) offer a potential unlimited source for functional human hepatocytes, since they can differentiate into hepatocyte-like cells displaying a characteristic hepatic morphology and expressing several hepatic markers. Such… Show all
Associated cell lines:
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Dr. Johan Hyllner
Monitoring differentiation of human embryonic stem cells using real-time PCR
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 16081663 DOI: 10.1634/stemcells.2005-0093Abstract:
There is a general lack of rapid, sensitive, and quantitative methods for the detection of differentiating human embryonic stem cells (hESCs). Using light microscopy and immunohistochemistry, we observed that morphological changes of differentiating … Show all
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Dr. Johan Hyllner
Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 17346923 DOI: 10.1016/j.tiv.2007.01.021Abstract:
Human embryonic stem cells (hESCs) offer a potential unlimited source for functional human hepatocytes, since hESCs can differentiate into hepatocyte-like cells displaying a characteristic hepatic morphology and expressing several hepatic markers. Th… Show all
Associated cell lines:
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Dr. Johan Hyllner
Artifactual insulin release from differentiated embryonic stem cells
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 15448090Abstract:
Several recent reports claim the generation of insulin-producing cells from embryonic stem cells via the differentiation of progenitors that express nestin. Here, we investigate further the properties of these insulin-containing cells. We find that a… Show all
Associated cell lines:
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Dr. Johan Hyllner
Large-scale propagation of four undifferentiated human embryonic stem cell lines in a feeder-free culture system
2008-01-06 00:00:00.0 6th Jan 2008Journal etc.
PubMed: 15965986 DOI: 10.1002/dvdy.20459Abstract:
We describe an improved and more robust protocol for transfer and subsequent propagation of human embryonic stem cells under feeder-free conditions. The results show that mechanical dissociation for transfer of the human embryonic stem cells to Matri… Show all
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Dr. Johan Hyllner
Derivation of a xeno-free human embryonic stem cell line
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 16741223 DOI: 10.1634/stemcells.2006-0130Abstract:
Elimination of all animal material during both the derivation and long-term culture of human embryonic stem cells (hESCs) is necessary prior to future application of hESCs in clinical cell therapy. The potential consequences of transplanting xeno-con… Show all
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Dr. Johan Hyllner
Molecular and pharmacological properties of human embryonic stem cell-derived cardiomyocytes
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 17138763Abstract:
Human embryonic stem cells (hESCs) can be coaxed to differentiate into specific cell types, including cardiomyocyte-like cells. These cells express cardiac-specific markers and display functional similarities to their adult counterparts. Based on the… Show all
Associated cell lines:
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Dr. Johan Hyllner
Derivation, characterization and differentiation of human embryonic stem cells
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 15153613 DOI: 10.1634/stemcells.22-3-367Abstract:
The derivation of human embryonic stem (hES) cells establishes a new avenue to approach many issues in human biology and medicine for the first time. To meet the increased demand for characterized hES cell lines, we present the derivation and charact… Show all
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Dr. Johan Hyllner
Differentiating human embryonic stem cells express a unique housekeeping gene signature
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 17284652 DOI: 10.1634/stemcells.2006-0247Abstract:
Housekeeping genes (HKGs) are involved in basic functions needed for the sustenance of the cell and are assumed to be constitutively expressed at a constant level. Based on these features, HKGs are frequently used for normalization of gene expression… Show all
Associated cell lines:
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Dr. Johan Hyllner
Human embryonic stem cells have a unique epigentic signature
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
Associated cell lines:
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Dr. Johan Hyllner
Clonal derivation and characterization of human embryonic stem cell lines
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 16324761 DOI: 10.1016/j.jbiotec.2005.10.010Abstract:
Human embryonic stem cells (hESC) are isolated as clusters of cells from the inner cell mass of blastocysts and thus should formally be considered as heterogeneous cell populations. Homogenous hESC cultures can be obtained through subcloning. Here, w… Show all
Associated cell lines:
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Dr. Johan Hyllner
Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 16544187 DOI: 10.1007/s10577-006-1019-8Abstract:
There have been recent reports of human embryonic stem cell (hESC) lines developing chromosomal aberrations after long-term culture, indicating an unstable genomic status due to the in vitro milieu. This raises concern, since it would limit their use… Show all
Associated cell lines:
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Dr. Johan Hyllner
High-resolution analysis of the subtelomeric regions of human embryonic stem cells
2008-01-04 00:00:00.0 4th Jan 2008Journal etc.
PubMed: 15790769 DOI: 10.1634/stemcells.2004-0254Abstract:
The use of human embryonic stem cells (hESCs) in most applications is dependent on their undifferentiated proliferation in vitro. Recent studies have illustrated the possibility that chromosomal changes may occur in hESCs during in vitro propagation … Show all
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Prof. Dr. Douglas A. Melton
Derivation of Embryonic Stem-cell Lines from Human Blastocysts
2007-12-20 00:00:00.0 20th Dec 2007Journal etc.
PubMed: 14999088 DOI: 10.1056/NEJMsr040330Abstract:
Embryonic stem cells have the unique ability to form all adult cell types. Harnessing this potential may provide a source of cells to replace those that are lost or impaired as a result of disease. Moreover, the derivation of human embryonic … Show all
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Prof. Dr, Karen Sermon
Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders.
2007-12-11 00:00:00.0 11th Dec 2007Journal etc.
PubMed: 16284066 DOI: 10.1093/humrep/dei345Abstract:
BACKGROUND: Human embryonic stem (hES) cells are pluripotent cells usually derived from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all three embryonic germ layers, hES cells represent an important materia… Show all
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Dr. Claus Yding Andersen
Regional differences in expression of specific markers for human embryonic stem cells
2007-12-04 00:00:00.0 4th Dec 2007Journal etc.
PubMed: 17623545Abstract:
Characterization of human embryonic stem cell (hESC) lines derived from the inner cell masses of blastocysts generally includes expression analysis of markers such as OCT4, NANOG, SSEA3, SSEA4, TRA-1-60 and TRA-1-81. Expression is usually detected by… Show all
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Dr. Anette Gabrielsen
Derivation and characterization of four new human embryonic stem cell lines: the Danish experience.
2007-11-25 00:00:00.0 25th Nov 2007Journal etc.
PubMed: 16454946Abstract:
In September 2003, legislation approved in Denmark legalized work on surplus human embryos from IVF for clinical purposes to establish human embryonic stem (ES) cell cultures. The aim of this study was to establish such stem cell lines. Fresh surplus… Show all