Human induced pluripotent stem cell line (QBRIi013-A) derivation from a 6-year-old female diagnosed with Autism spectrum disorder (ASD) and intellectual disability (ID)
Summary
Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder characterized by social interaction, behavior, and communication challenges. Here, we generated an induced pluripotent stem cell (iPSC) line, QBRIi013-A using a non-integrating Sendai virus from a 6-year-old female diagnosed with ASD and intellectual disability. The QBRIi013-A cell line was fully characterized and exhibited a pluripotency capacity and trilineage differentiation potential. Furthermore, it showed normal karyotype and genetic identity to the patient's PBMCs. Consequently, this iPSC line provides a valuable cell model in understanding the molecular mechanism underlying the complexities of ASD pathogenesis. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Elsayed AK, Salloum-Asfar S, Abdulla SA |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Oct;56:102500 |
| PubMed | 34438163 |
| DOI | 10.1016/j.scr.2021.102500 |