What is hPSCreg?

hPSCreg is a global registry for human pluripotent stem cell lines (hPSC-lines). It aims to provide to the community

  • a central and searchable hub for available hPSC-lines
  • a central registry of clinical studies based on hPSC-lines
  • a standardized identifier for hPSC-lines and register of these standard names
  • a trustworthy data source for hPSC-lines by verifying the ethical and biological conformity of registered lines based on community standards
  • comparability of quality standards in hPSC research
  • certification of quality and ethical provenance of hPSC-lines
  • a platform where any scientist or institution generating or working with PSC lines can register their cell lines, projects or clinical studies

Why register cell lines?


  • establishes a standard name and unique identifier for the cell line, making it recognizable throughout publication and data resources.
  • verifies ethical provenance and scientific evidence for pluripotency using standardized criteria
  • offers access to information related to the individual PSC-lines such as derivation, cultivation, genetic constitution and application
  • provides secure, findable and unrestricted storage of valuable data on hPSC-lines
  • guarantees global visibility, confidence in ethical provenance, validation of characterization data, and comparability with other registered lines

What is registered?

  • almost all information related to hPSC-lines, including ethical provenance, procurement, derivation process, genetic and expression data and other molecular or biological characteristics, use, and quality of the line can be registered.
  • data and information on each line can be updated, edited and completed.
  • more information on data quality and data standards can be found in this webinar: https://www.youtube.com/watch?v=iz2z5ztCZXg

Why register research projects in hPSCreg?

Research Project Registration

  • establishes a transparent link between a research project and qualified hPSC-lines that are registered in hPSCreg
  • promotes transparency of hPSC line usage in publicly or privately funded research projects

What is the Clinical study database for hPSC-based cell therapies?

The clinical study database aims at providing a comprehensive overview of clinical studies that specifically use human pluripotent stem cells (hPSC) or hPSC-derived cells. These include human embryonic stem cells (hESC), human induced pluripotent stem cells (hiPSC), stem cells created by stem cell nuclear transfer (SCNT) and parthenogenetic stem cells, comprising trials worldwide where patients are actively treated with hPSC – derived cells or a product thereof.

Registration of clinical studies in hPSCreg is (a) based on information retrieved from multiple public resources and (b) based on information provided by individual study teams.

The database also provides links to the original source of the information (i.e. clinical trial registries worldwide) and will facilitate the unique identification of trials by grouping together multiple records about the same trial.

Why register clinical studies in hPSCreg?

Clinical Study Registration

  • tracks the translational pathway of hPSCs to clinical application
  • specifically highlights the progress of hPSC-derived cell therapies across multiple regulatory jurisdictions

Collaboration and Cooperation

hPSCreg offers an open platform for coordination and cooperation in the area of hPSC research and application, thus avoiding redundancy and promoting reproducibility in research. hPSCreg collaborates with registries, cell banks and international initiatives worldwide.

History and funding

hPSCreg was established in 2007 as the European human embryonic stem cell registry (hESCreg) and is supported by the European Commission. You can also find hPSCreg at re3data.org, FAIRsharing.org, and Identifiers.org. Should you experience any problems interacting with the database or would like to contribute to its further development please contact us.