Induced human pluripotent stem cells (HEBHMUi013-A) derived from a patient of sporadic Alzheimer's disease


Sporadic Alzheimer's disease (sAD) is the most common neurodegenerative disease worldwide, which is characterized by the progressive cognitive dysfunction and behavioral impairment. Here, we generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) isolated from a 78-year-old male patient clinically diagnosed with sAD. The iPSC line expressed pluripotency markers, showed normal karyotype, and had the ability to differentiate into three germ layers in vitro. This iPSC line may provide a powerful tool for modeling AD in vitro and studying the pathogenesis of sAD. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Cao S, Guo R, Fu Z, Liu Y, Wu T, Zhou Z, Zhang J, Liu X, Song Y, Ma J
Journal Stem cell research
Publication Date 2023 Mar 2;68:103052
PubMed 36870256
DOI 10.1016/j.scr.2023.103052

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