HEBHMUi013-A

General

Cell Line

hPSCreg name HEBHMUi013-A
Cite as:
HEBHMUi013-A (RRID:CVCL_C7RE)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
UKBi011-A-1
(iLB-AD + ApoE KO)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-2
(ApoE 2/2)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-3
(ApoE 3/3)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-4
(ApoE 3/4)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
STBCi006-A-1
(ApoE KO)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
STBCi006-A-3
(ApoE 3/3)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
STBCi006-A-4
(ApoE 3/4)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
MUNIi013-A
(BAD4, sAD3)
Donor diseases:
Alzheimer's Disease
IPTi003-A
(15M0010)
Donor diseases:
obsolete_Alzheimer's disease
IPTi004-A
(15M0011)
Donor diseases:
obsolete_Alzheimer's disease
SIAISi007-A
(ZSJ)
Donor diseases:
Alzheimer's Disease
UMi042-A-1
(408737 CB9)
Donor diseases:
Alzheimer's Disease
UKBi011-A
(iLB-AD-169bm-s24)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
MUNIi021-A
(sAD5)
Donor diseases:
Alzheimer's Disease
BIOTi001-A
(BIOT-7183-PSEN1)
Donor's gene variants:
PSEN1
Donor diseases:
obsolete_Alzheimer's disease
MUNIi011-A
(BAD1, sAD1)
Donor diseases:
Alzheimer's Disease
MUNIi012-A
(BAD2, sAD2)
Donor diseases:
Alzheimer's Disease
UMi041-A
(410730)
Donor diseases:
Alzheimer's Disease
IPTi002-A
(15F0009)
Donor diseases:
obsolete_Alzheimer's disease
SIAISi006-A
(JJY)
Donor diseases:
Alzheimer's Disease
UMi043-A
(AD 381852 clone #1)
Donor diseases:
Alzheimer's Disease
STBCi071-C
(SFC057-07-02)
Donor diseases:
Alzheimer disease
ZZUi013-A
(ZZU-iPS-AD-MEOX2-001)
Donor diseases:
obsolete_Alzheimer's disease
STBCi097-A
(SFC055-04-02)
Donor diseases:
Alzheimer disease
STBCi097-B
(SFC055-04-01)
Donor diseases:
Alzheimer disease
Last update 28th January 2023
User feedback
No feedback available yet.

Login to share your feedback, experiences or results with the research community.

Provider

Generator Hebei Medical University (HEBHMU)
Owner Hebei Medical University (HEBHMU)
Distributors
Derivation country China

External Databases

BioSamples SAMEA112356743
Cellosaurus CVCL_C7RE
Wikidata Q117704481

General Information

Publications
* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex male

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Synonyms
  • Alzheimer's Disease
  • Alzheimer disease
  • Alzheimer Disease
  • Alzheimer dementia
  • Alzheimer's Dementia
  • Alzheimer's disease
  • Alzheimer's disease, unspecified
show more synonyms

External Databases (Donor)

BioSamples SAMEA112356744

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information https://www.hebmu.edu.cn/
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? No information
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Ethics Committee of Hebei Medical University
Approval number HEBHMU-20190017
Do you have obligations to third parties in regard to the use of the cell line? Yes
Please describe: Third Party should sign an cooperation agreement with my institution, and the usage of the cell line will be clarified in detail.
Are you aware of any further constraints on the use of the donated embryo/tissue or derived cells? Yes
Further constraints on use Only for research and clinical trial.
Is there an MTA available for the cell line? Yes
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Is reprogramming vector detectable?
Yes
Methods used
PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
SOX2
Yes
SSEA-4
Yes
TRA 1-60
Yes
NANOG
Yes
Score:
Marker Present Absent
mCpG
OCT4
Differentiation Potency
Hepatocyte
Ont Id: CL_0000182
In vitro spontaneous differentiation
Smooth Muscle Cell
Ont Id: CL_0000192
In vitro spontaneous differentiation
Neuroepithelial Stem Cell
Ont Id: CL_0002259
In vitro spontaneous differentiation

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
22+XY
Passage number: 21

Other Genotyping (Cell Line)