Generation of integration-free human induced pluripotent stem cells from a patient with sporadic Parkinson's disease
Summary
A human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson's disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, SOX2/KLF4, L-MYC/LIN28). The KKUi002-A iPSCs displayed typical iPSC morphology, expressed pluripotency markers, differentiated into derivatives of three germ layers, and had a normal karyotype. These PD-derived iPSCs can be used to understand the mechanism underlying PD pathogenesis. Copyright © 2024. Published by Elsevier B.V.
| Authors | Lee Y, Jeong D, Ham S, Son J, Ko K |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Apr 8;77:103416 |
| PubMed | 38615589 |
| DOI | 10.1016/j.scr.2024.103416 |