Generation of integration-free human induced pluripotent stem cells from a patient with sporadic Parkinson's disease


A human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson's disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, SOX2/KLF4, L-MYC/LIN28). The KKUi002-A iPSCs displayed typical iPSC morphology, expressed pluripotency markers, differentiated into derivatives of three germ layers, and had a normal karyotype. These PD-derived iPSCs can be used to understand the mechanism underlying PD pathogenesis. Copyright © 2024. Published by Elsevier B.V.

Authors Lee Y, Jeong D, Ham S, Son J, Ko K
Journal Stem cell research
Publication Date 2024 Jun;77:103416
PubMed 38615589
DOI 10.1016/j.scr.2024.103416

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