Reprogramming of a human induced pluripotent stem cell line from a long QT syndrome patient harboring a heterozygous mutation of c.1537C > T in SCN5A gene

Summary

Long QT syndrome (LQTS) often causes malignant arrhythmia and syncope. Mutations in the SCN5A gene are the main cause of type 3 LQTS. In this study, we generated a human induced pluripotent stem cell line ZJYYPHi001-A from a female LQTS patient harboring a heterozygous mutation in SCN5A using non-integrative Sendai virus. This cell line expressed pluripotency markers, had the normal karyotype and could differentiate into three germ layers in vitro. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Chen J, Song Y, Gu J, Chen L
Journal Stem cell research
Publication Date 2021 Oct 18;57:102576
PubMed 34678660
DOI 10.1016/j.scr.2021.102576

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