Reprogramming of a human induced pluripotent stem cell line from a long QT syndrome patient harboring a heterozygous mutation of c.1537C > T in SCN5A gene
Summary
Long QT syndrome (LQTS) often causes malignant arrhythmia and syncope. Mutations in the SCN5A gene are the main cause of type 3 LQTS. In this study, we generated a human induced pluripotent stem cell line ZJYYPHi001-A from a female LQTS patient harboring a heterozygous mutation in SCN5A using non-integrative Sendai virus. This cell line expressed pluripotency markers, had the normal karyotype and could differentiate into three germ layers in vitro. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Chen J, Song Y, Gu J, Chen L |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Dec;57:102576 |
| PubMed | 34678660 |
| DOI | 10.1016/j.scr.2021.102576 |