Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion


Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we generated human induced pluripotent stem cells (iPSCs) from a SCZ patient with an exonic deletion of ASTN2. The generated iPSCs carried ASTN2 deletion and showed typical iPSC morphology, pluripotency marker expression, normal chromosomal aneuploidy, and the capacity to differentiate into three germ layers. This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N
Journal Stem cell research
Publication Date 2018 Jul;30:81-84
PubMed 29803967
DOI 10.1016/j.scr.2018.05.013

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