Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer
Summary
Here, we describe the first characterization of epicardial EV secretion, which can signal to promote proliferation of cardiomyocytes in infarcted mouse hearts and in a human model of myocardial injury, resulting in enhanced contractile function. Analysis of exosome cargo in mouse and human identified conserved pro-regenerative miRs, which in combination recapitulated the therapeutic effects of promoting cardiomyocyte proliferation. © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.
| Authors | Del Campo CV, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR |
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| Journal | Cardiovascular research |
| Publication Date | 2022 Jan 29;118(2):597-611 |
| PubMed | 33599250 |
| PubMed Central | PMC8803084 |
| DOI | 10.1093/cvr/cvab054 |