Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer


Here, we describe the first characterization of epicardial EV secretion, which can signal to promote proliferation of cardiomyocytes in infarcted mouse hearts and in a human model of myocardial injury, resulting in enhanced contractile function. Analysis of exosome cargo in mouse and human identified conserved pro-regenerative miRs, which in combination recapitulated the therapeutic effects of promoting cardiomyocyte proliferation. © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

Authors Del Campo CV, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR
Journal Cardiovascular research
Publication Date 2022 Jan 29;118(2):597-611
PubMed 33599250
PubMed Central PMC8803084
DOI 10.1093/cvr/cvab054

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