Generation of Duchenne muscular dystrophy patient-specific induced pluripotent stem cell line lacking exons 45-50 of the dystrophin gene (IITi001-A)
Summary
Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene. We generated induced pluripotent stem cells (iPSCs) from a 13-year-old male patient carrying a deletion mutation of exons 45-50; iPSCs were subsequently differentiated into cardiomyocytes. iPSCs exhibit expression of the pluripotent markers (SOX2, NANOG, OCT4), differentiation capacity into the three germ layers, normal karyotype, genetic identity to the skin biopsy dermal fibroblasts and the patient-specific dystrophin mutation. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Reiter I, Ramchandren S, Arad M, Michele DE, Binah O |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2018 May;29:111-114 |
| PubMed | 29653394 |
| PubMed Central | PMC5999581 |
| DOI | 10.1016/j.scr.2018.03.023 |