Generation of iPSC lines from peripheral blood mononuclear cells of identical twins both suffering from type 2 diabetes mellitus and one of them additionally diagnosed with atherosclerosis
Summary
Here we describe the generation of induced pluripotent stem cell (iPSC) lines from peripheral blood samples of identical twin sisters with type 2 diabetes mellitus (DM2). Two clonal lines from each patient (HU-DM2-A-1, HU-DM2-A-2 and HU-DM2-B-1, HU-DM2-B-2) were established via Sendai viral reprograming of peripheral blood mononuclear cells, and characterized to confirm pluripotency and genetic integrity. The established iPSC lines can help to investigate DM2 related cellular phenotypes and provide a model system for drug testing. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Szabó E, Reé D, Jezsó B, Vincze K, Földes G, Molnár AÁ, Réthelyi JM, Apáti Á |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102051 |
| PubMed | 33099106 |
| DOI | 10.1016/j.scr.2020.102051 |