Generation of a human induced pluripotent stem cell line (VRFi001-A) from orbital adipose tissue of a bilateral retinoblastoma patient with heterozygous RB1 gene deletion
Retinoblastoma (RB) is a pediatric intraocular tumor caused by mutations in retinoblastoma (RB1) gene. We have generated induced pluripotent stem cell line VRFi001-A from a bilateral retinoblastoma patient with heterozygous RB1 gene deletion. The iPSC line VRFi001-A retained the mutation and expressed pluripotency markers, had a normal karyotype and was capable of trilineage differentiation. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Vincent A, Khetan V, Rishi P, Suganeswari G, Krishnakumar S, Krishnan UM, Parameswaran S|
|Journal||Stem cell research|
|Publication Date||2018 May;29:42-45|