Generation of a human induced pluripotent stem cell line (VRFi001-A) from orbital adipose tissue of a bilateral retinoblastoma patient with heterozygous RB1 gene deletion
Summary
Retinoblastoma (RB) is a pediatric intraocular tumor caused by mutations in retinoblastoma (RB1) gene. We have generated induced pluripotent stem cell line VRFi001-A from a bilateral retinoblastoma patient with heterozygous RB1 gene deletion. The iPSC line VRFi001-A retained the mutation and expressed pluripotency markers, had a normal karyotype and was capable of trilineage differentiation. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Vincent A, Khetan V, Rishi P, Suganeswari G, Krishnakumar S, Krishnan UM, Parameswaran S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2018 May;29:42-45 |
| PubMed | 29579639 |
| DOI | 10.1016/j.scr.2018.03.012 |