Generation of two induced pluripotent stem cell lines from patients with X-linked Alport syndrome


Mutations in COL4A5 on chromosome Xq22 cause X-linked Alport syndrome (XLAS). In this study, we generated two human induced pluripotent stem cell (iPSC) lines from two male patients carrying mutation c.796C > T (p.R266X) in COL4A5 gene. The two iPSC lines retain the original mutation, possess normal karyotypes, express pluripotency markers and bear differentiation potential. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Ma Y, Wang Z, Gao M, Liu X, Sun W, Gong Y, Sun G, Liu G
Journal Stem cell research
Publication Date 2021 May;53:102343
PubMed 33878711
DOI 10.1016/j.scr.2021.102343

Research Projects

Cell Lines