Development and identification of a induced pluripotent stem cells line (SMBCi013-A) derived from urine cells of a patient with Wilson's disease
Summary
The human induced pluripotent stem cell (iPSC) line SMBCi013-A was derived from urine cells of a 29 year old male affected by Wilson's disease. Two heterozygous mutations in the ATP7B gene were detected by whole exon sequencing (c.2303C > A and c.3334C > T). The reprogramming factors (OCT-4, SOX-2, KLF4, miR-302-367) were delivered using non-integrating episomal plasmids. The resulting iPSCs were pluripotent, have chromosomal stability, and the ability to differentiate into the three germ layers. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhao Y, Cui Y, Luan J, Wang J, Shi L, Han Z, Han J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Mar;59:102650 |
| PubMed | 34995846 |
| DOI | 10.1016/j.scr.2021.102650 |