Development and identification of a induced pluripotent stem cells line (SMBCi013-A) derived from urine cells of a patient with Wilson's disease

Summary

The human induced pluripotent stem cell (iPSC) line was constructed from urine cells of a 29 years old male, who attacted by Wilson's disease defected in the ATP7B gene. Two heterozygous mutations of ATP7B gene were revealed by whole exon sequencing (c.2303C > A and c.3334C > T). The reprogramming factors (OCT-4, SOX-2, KLF4, miR-302-367) were delivered using a non-integrative plasmid. The iPSCs were pluripotency, hereditary stability, and the ability to differentiate into three layers. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zhao Y, Cui Y, Luan J, Wang J, Shi L, Han Z, Han J
Journal Stem cell research
Publication Date 2021 Dec 30;59:102650
PubMed 34995846
DOI 10.1016/j.scr.2021.102650

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