Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient


We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Ma J, Guo R, Song Y, Zhang J, Feng B, Amponsah AE, Kong D, He J, Zhang W, Liu A, Wei L, Shen S, O'Brien T, Cui H
Journal Stem cell research
Publication Date 2019 Apr;36:101417
PubMed 30875588
DOI 10.1016/j.scr.2019.101417

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