Generation of an iPSC line (HRMSDUi001-A) from an azoospermic patient with 45,XY,der(13;14)(q10;q10) karyotype
Summary
Robertsonian translocation between chromosomes 13 and 14 is reported to be a cause of male infertility. Here, we established an iPSC line (HRMSDUi001-A) from an azoospermic patient with 45,XY,der(13;14)(q10;q10) karyotype. Peripheral blood mononuclear cells were reprogrammed to generate hiPSCs by non-integrating delivery of OCT4, SOX2, KFL4 and MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and carried 45,XY,der(13;14)(q10;q10) karyotype. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Guo L, Zhao Z, Zhao S, Kong F, Yuan M |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Aug;55:102453 |
| PubMed | 34284274 |
| DOI | 10.1016/j.scr.2021.102453 |