Generation of an induced pluripotent stem cell line BIOi004-A from a patient with autosomal dominant retinitis pigmentosa
Summary
RP33 is a form of autosomal dominant retinitis pigmentosa (adRP), which is caused by heterozygous variants in the SNRNP200 gene. Peripheral blood mononuclear cells (PBMCs) were isolated from a 31-year-old Chinese patient with a heterozygous c.2359G > A variant in the SNRNP200 gene. PBMCs were reprogrammed into an induced pluripotent stem cell (iPSC) line BIOi004-A. The established iPSC line had normal karyotype, expressed undifferentiated stem cell markers, and was capable to differentiate into the three germ layers in vivo. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhang X, Li Y, Jin ZB, Zhang XH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 May 17;86:103738 |
| PubMed | 40403403 |
| DOI | 10.1016/j.scr.2025.103738 |