Establishment of an integration-free human induced pluripotent stem cell line (TJCi001-A) from normal bone marrow-derived mesenchymal stem cells


Bone marrow-derived mesenchymal stem cells (BM-MSCs) possess excellent therapeutic potential for the treatment of various diseases including graft-versus-host disease, rheumatoid arthritis, osteoarthritis, and multiple sclerosis. Here, we generated an induced pluripotent stem cell (iPSC) line from BM-MSCs employing a non-integrating episomal vector. The generated iPSCs expressed pluripotency markers, showed a normal karyotype, and exhibited the potential for in vitro differentiation into three germ layers. This iPSC line can be used as a healthy control in stem cell therapeutics and disease modeling studies. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Choi NY, Lee Y, Park YS, Ko K, Park B, Koh YG
Journal Stem cell research
Publication Date 2021 Aug;55:102484
PubMed 34371346
DOI 10.1016/j.scr.2021.102484

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