Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype


Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Peitz M, Bechler T, Thiele CC, Veltel M, Bloschies M, Fliessbach K, Ramirez A, Brüstle O
Journal Stem cell research
Publication Date 2018 May;29:250-253
PubMed 29753274
DOI 10.1016/j.scr.2018.04.011

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