Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system


We demonstrate the efficient expansion of hPSC, controlled differentiation to renal progenitors and further specification to polarized tubular epithelial cells. This is the first report employing biolevitation and matrix-coated beads in a completely defined medium for the scalable and potentially automatable production of functional human PTEC. © 2022 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.

Authors Ngo TTT, Rossbach B, Sébastien I, Neubauer JC, Kurtz A, Hariharan K
Journal Cell proliferation
Publication Date 2022 Mar;55(3):e13190
PubMed 35102634
PubMed Central PMC8891564
DOI 10.1111/cpr.13190

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