Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications


Retinopathy is a well-known ocular complication that occurs in patients with type 2 diabetes (T2D). Recent evidence also indicates that diabetic patients have an increased prevalence of dry eye syndrome. However, the etiologies of both diabetic retinopathy (DR) and dry eye disease are complex, and their associations with T2D remains to be fully understood. Patient-derived human induced pluripotent stem cells (hiPSCs) enable the generation of disease-specific retinal tissues such as retinal pigment epithelium and lacrimal gland to model disease pathogenesis. Here, we describe the establishment of three hiPSC lines from T2D patients with PDR or dry eye disease. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Chu EP, Cho CH, Lee WJ, Lee IT, Cheng IF, Kuo TC, Chen RY, Sheu WH, Shen CN
Journal Stem cell research
Publication Date 2020 Dec;49:102109
PubMed 33370876
DOI 10.1016/j.scr.2020.102109

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