Generation and characterization of PBMCs-derived human induced pluripotent stem cell (iPSC) line SDQLCHi051-A from an autism spectrum disorder patient with compound CHD8 gene mutations
Summary
CHD8 mutation is a case of genetic related autism spectrum disorder(ASD), In our research, We describe here the derivation of the iPSC line SDQLCHi051-A from a patient with autism spectrum disorder (ASD) due to two heterozygote mutations (c.6728G > A and c.3876 T > G) in the CHD8 gene. The resulting iPSC line has typical iPSCs characteristics, including pluripotency and trilineage differentiation hallmarks. Copyright © 2023. Published by Elsevier B.V.
| Authors | Fan Y, Li Y, Yang X, Zhang H, Wang B, Guan J, Gao J, Ma X, Liu Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Jun;69:103114 |
| PubMed | 37229974 |
| DOI | 10.1016/j.scr.2023.103114 |