Generation and characterization of PBMCs-derived human induced pluripotent stem cell (iPSC) line SDQLCHi051-A from an autism spectrum disorder patient with compound CHD8 gene mutations


CHD8 mutation is a case of genetic related autism spectrum disorder(ASD), In our research, We describe here the derivation of the iPSC line SDQLCHi051-A from a patient with autism spectrum disorder (ASD) due to two heterozygote mutations (c.6728G > A and c.3876 T > G) in the CHD8 gene. The resulting iPSC line has typical iPSCs characteristics, including pluripotency and trilineage differentiation hallmarks. Copyright © 2023. Published by Elsevier B.V.

Authors Fan Y, Li Y, Yang X, Zhang H, Wang B, Guan J, Gao J, Ma X, Liu Y
Journal Stem cell research
Publication Date 2023 Jun;69:103114
PubMed 37229974
DOI 10.1016/j.scr.2023.103114

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