An achievement has been made in establishing an induced pluripotent stem cell line (SDPHi005-A) from a healthy Chinese male donor


Successfully transforming isolated peripheral blood mononuclear cells (PBMCs) from a healthy male into induced pluripotent stem cells (iPSCs) was achieved using non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs exhibited a normal karyotype, expressed pluripotency markers, and demonstrated the ability to differentiate into three germ layers in vitro. This iPSC line may be employed for subsequent research purposes. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Shao J, Jin Y, Shao C, Zhang X, Yang G
Journal Stem cell research
Publication Date 2024 Jun;77:103393
PubMed 38531229
DOI 10.1016/j.scr.2024.103393

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