An achievement has been made in establishing an induced pluripotent stem cell line (SDPHi005-A) from a healthy Chinese male donor
Summary
Successfully transforming isolated peripheral blood mononuclear cells (PBMCs) from a healthy male into induced pluripotent stem cells (iPSCs) was achieved using non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs exhibited a normal karyotype, expressed pluripotency markers, and demonstrated the ability to differentiate into three germ layers in vitro. This iPSC line may be employed for subsequent research purposes. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Shao J, Jin Y, Shao C, Zhang X, Yang G |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Mar 16;77:103393 |
| PubMed | 38531229 |
| DOI | 10.1016/j.scr.2024.103393 |