In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells
Summary
This study demonstrates the suitability of iPS cells in modeling RYR2-related cardiac disorders in vitro and opens new opportunities for investigating the disease mechanism in vitro, developing new drugs, predicting their toxicity, and optimizing current treatment strategies. Copyright © 2011 S. Karger AG, Basel.
| Authors | Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnáiz-Cot JJ, Rosa AO, Nguemo F, Matzkies M, Dittmann S, Stone SL, Linke M, Zechner U, Beyer V, Hennies HC, Rosenkranz S, Klauke B, Parwani AS, Haverkamp W, Pfitzer G, Farr M, Cleemann L, Morad M, Milting H, Hescheler J, Saric T |
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| Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology |
| Publication Date | 2011;28(4):579-92 |
| PubMed | 22178870 |
| PubMed Central | PMC3709175 |
| DOI | 10.1159/000335753 |