Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells


Combination of human iPSC technology with either lentiviral vector technology or designer nuclease-based genome editing allows for the generation of transgenic iPSC-derived macrophages with stable transgene expression which may be useful for novel cell and gene replacement therapies.

Authors Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N
Journal Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Publication Date 2017 Jun;44(3):135-142
PubMed 28626364
PubMed Central PMC5473066
DOI 10.1159/000477129

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