Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells
Summary
Combination of human iPSC technology with either lentiviral vector technology or designer nuclease-based genome editing allows for the generation of transgenic iPSC-derived macrophages with stable transgene expression which may be useful for novel cell and gene replacement therapies.
| Authors | Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N |
|---|---|
| Journal | Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie |
| Publication Date | 2017 Jun;44(3):135-142 |
| PubMed | 28626364 |
| PubMed Central | PMC5473066 |
| DOI | 10.1159/000477129 |