Generation of induced pluripotent stem cell line (ZZUi005-A) from a 21-year-old patient with a novel RAB39B gene mutation in X-linked juvenile parkinsonism
Summary
Ras-related protein 39B (RAB39B) mutation has been reported as a potential cause of X-linked Parkinson's disease (PD), a rare form of familial PD. Recently, a novel RAB39B mutation was identified in an X-linked juvenile parkinsonism family and the dermal fibroblasts of the patient were obtained and successfully induced to induced pluripotent stem cells (iPSCs) by the human OSKM transcription factors using the Sendai-virus delivery system. Our model may offer a good platform for further research of the pathomechanism, drug testing, and gene therapy of this disease. Copyright © 2017. Published by Elsevier B.V.
| Authors | Wang Y, Sun H, Wang Z, Yang Z, Shi M, Yang J, Liu Y, Liu H, Zhang S, Shi C, Xu Y |
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| Journal | Stem cell research |
| Publication Date | 2017 Dec;25:132-135 |
| PubMed | 29128816 |
| DOI | 10.1016/j.scr.2017.10.021 |