Generation of a human induced pluripotent stem cell line (CMCi002-A) from a patient with Gitelman's syndrome


We established a human induced pluripotent stem cells (hiPSC) line (CMCi002-A) from peripheral blood mononuclear cells (PBMCs) of 29-year-old male with Gitelman's syndrome (GIT) caused by the mutation of solute carrier family 12 member 3 (SLC12A3) gene using Sendai virus. The GIT-hiPSCs showed a typical human embryonic stem cell like morphology and expressed all pluripotency-associated markers, exhibited normal karyotype and were capable of differentiating into cells representative of three germ layers. Copyright © 2020. Published by Elsevier B.V.

Authors Lim SW, Shin YJ, Cui S, Ko EJ, Lee KI, Lee JY, Chung BH, Yang CW
Journal Stem cell research
Publication Date 2020 Dec;49:102110
PubMed 33370877
DOI 10.1016/j.scr.2020.102110

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