Generation of a human induced pluripotent stem cell line (SYSUTFi001-A) from infiltrating cytotoxic T cells in hepatocellular carcinoma (HCC)
Summary
In this study, we report a novel induced pluripotent stem cell (iPSC) line SYSUTFi001-A derived from cytotoxic T cells (CTLs) infiltrating in hepatocellular carcinoma (HCC), using an integrative Sendai virus vector. This pluripotent cell line shows a normal karyotype and can be redifferentiated to the rejuvenated CTLs targeted to HCC. The cell line SYSUTFi001-A can be further used to perform vitro and vivo anti-tumor assays and design future cell replacement therapies. Copyright © 2022. Published by Elsevier B.V.
| Authors | Yang D, Ling X, Liu F, Duan J, Bai F, Hu A |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102962 |
| PubMed | 36375283 |
| DOI | 10.1016/j.scr.2022.102962 |