Generation of a human induced pluripotent stem cell line (SYSUTFi001-A) from infiltrating cytotoxic T cells in hepatocellular carcinoma (HCC)


In this study, we report a novel induced pluripotent stem cell (iPSC) line SYSUTFi001-A derived from cytotoxic T cells (CTLs) infiltrating in hepatocellular carcinoma (HCC), using an integrative Sendai virus vector. This pluripotent cell line shows a normal karyotype and can be redifferentiated to the rejuvenated CTLs targeted to HCC. The cell line SYSUTFi001-A can be further used to perform vitro and vivo anti-tumor assays and design future cell replacement therapies. Copyright © 2022. Published by Elsevier B.V.

Authors Yang D, Ling X, Liu F, Duan J, Bai F, Hu A
Journal Stem cell research
Publication Date 2022 Nov 7;65:102962
PubMed 36375283
DOI 10.1016/j.scr.2022.102962

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