Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3
Summary
The induced pluripotent stem cell (iPSC) line XHCSUi001-A generated from urine cells of a female spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) patient by using the integration-free methods. The induced XHCSUi001-A retained the disease-causing ATXN3 mutation, expressed pluripotency markers, exhibited a normal karyotype and retained the ability to differentiate into the three germ layers in-vitro and in-vivo. This newly induced iPSC line could be a potential tool for researching the disease-specific mechanisms and drug screening of SCA3/MJD. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | He L, Ye W, Chen Z, Wang C, Zhao H, Li S, Peng L, Han X, Zhou T, Li Z, Tang B, Jiang H |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Oct;40:101555 |
| PubMed | 31491691 |
| DOI | 10.1016/j.scr.2019.101555 |