General

Cell Line
hPSCreg Name A standardised name that was automatically generated based on the cell line information. see Naming Tool	SKLRMi001-A-1
Alternative name(s)	AR repaired iPSCs
Cell line type	Human induced pluripotent stem cell (hiPSC)
Last update	15th February 2023
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Provider
Generator	State Key Laboratory of Reproductive Medicine, Nanjing Medical University (SKLRM) Contact: State Key Laboratory of Reproductive Medicine, Nanjing Medical University (SKLRM)
Owner	State Key Laboratory of Reproductive Medicine, Nanjing Medical University (SKLRM)
Distributors	State Key Laboratory of Reproductive Medicine, Nanjing Medical University (SKLRM)
Derivation country	China
External Databases
BioSamples	SAMEA112648452
CLO	CLO_0104463
General Information
* Is the cell line readily obtainable for third parties?	No
Subclone of	SKLRMi001-A

Donor Information

General Donor Information
Sex	male
Phenotype and Disease related information (Donor)
Diseases	A disease was diagnosed. Androgen insensitivity syndrome Androgen insensitivity syndrome in the OLS Synonyms Goldberg-Maxwell syndrome Testicular feminization syndrome Androgen resistance syndrome AIS Morris syndrome show more synonyms show less synonyms
External Databases (Donor)
BioSamples	SAMEA6649976

Ethics

Also have a look at the ethics information for the parental line SKLRMi001-A .

For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General
The source cell information can be found in the parental cell line SKLRMi001-A.
Reprogramming method
Vector type	Non-integrating
Vector	Episomal
Vector free reprogramming
Other
Derived under xeno-free conditions	Unknown
Derived under GMP?	Unknown
Available as clinical grade?	Unknown

Culture Conditions

Surface coating	Matrigel/Geltrex
Feeder cells	No
Medium	Essential 8™

Characterisation

No characterisation data could be found for this subclone. Please open parental cell line SKLRMi001-A .

Genotyping

Karyotyping (Cell Line)
Has the cell line karyotype been analysed?	Yes normal karyotype Karyotype.jpg
Other Genotyping (Cell Line)

Genetic Modification

Disease/phenotype related modifications	We corrected a pathogenic mutation from the SKLRMi001-A, and SKLRMi001-A-1 has the nomal genome. Genetic modifications AR (target) Type of modification Isogenic modification Chromosome location Xq12 Nucleotide sequence variant in HGVS format NM_000044.6:c.2710G>A Protein sequence variant in HGVS format NP_000035.2:p.V904M How has the target locus been modified? Repaired
Genetic modifications not related to a disease	AR (target) Type of modification Isogenic modification Chromosome location Xq12 Nucleotide sequence variant in HGVS format NM_000044.6:c.2710G>A Protein sequence variant in HGVS format NP_000035.2:p.V904M How has the target locus been modified? Repaired