Generation of induced pluripotent stem cell line, ICGi033-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease
Summary
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (HTT) protein. In HD, dysregulation of multiple cellular processes occurs, resulting in the death of medium spiny neurons of striatum. A line of induced pluripotent stem cells (iPSCs) ICGi033-A was obtained from peripheral blood mononuclear cells of a patient carrying 77 CAG repeats in the HTT gene. The iPSCs express pluripotency markers, have a normal karyotype, and differentiate into three germ layers: endoderm, ectoderm, mesoderm. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Grigor'eva EV, Malakhova AA, Sorogina DA, Pavlova SV, Malankhanova TB, Abramycheva NY, Klyushnikov SA, Illarioshkin SN, Zakian SM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Aug;63:102868 |
| PubMed | 35872525 |
| DOI | 10.1016/j.scr.2022.102868 |