Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation


Mutation in SLC7A14 gene causes autosomal recessive retinitis pigmentosa (arRP). Here we describe the generation and characterization of human induced pluripotent stem cell (hiPSC) lines of RP patient with SLC7A14 mutation and his healthy parents. hiPSCs were derived from peripheral blood mononuclear cells (PBMCs) reprogrammed with integration-free plasmids including the reprogramming factors OCT3/4, SOX2, MYC and KLF4. All the established hiPSC lines showed normal karyotype, pluripotency and differentiation capacity. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Li YP, Liu H, Jin ZB
Journal Stem cell research
Publication Date 2020 Dec;49:102075
PubMed 33207307
DOI 10.1016/j.scr.2020.102075

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