iPSC for modeling neurodegenerative disorders


Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researchers and medical personnel. In the present review we will discuss the application of induced Pluripotent Stem Cells (iPSCs) for cell-therapy replacement and disease modelling. The aim of iPSCs is to restore the functionality of the damaged tissue by replacing the impaired cells with competitive ones. To achieve this objective, iPSCs can be properly differentiated into virtually any cell fate and can be strongly translated into human health via in vitro and in vivo disease modeling for the development of new therapies, the discovery of biomarkers for several disorders, the elaboration and testing of new drugs as novel treatments, and as a tool for personalized medicine. © 2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

Authors Valadez-Barba V, Cota-Coronado A, Hernández-Pérez OR, Lugo-Fabres PH, Padilla-Camberos E, Díaz NF, Díaz-Martínez NE
Journal Regenerative therapy
Publication Date 2020 Dec;15:332-339
PubMed 33426236
PubMed Central PMC7770414
DOI 10.1016/j.reth.2020.11.006

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