Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
Summary
47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease. Copyright © 2017. Published by Elsevier B.V.
| Authors | Chen Y, Ou Z, Song B, Xian Y, Ouyang S, Xie Y, Xue Y, Sun X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2017 Aug;23:57-60 |
| PubMed | 28925367 |
| DOI | 10.1016/j.scr.2017.06.002 |