Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection
Summary
In summary, we present a defective phenotype in iMacΔF508 upon P. aeruginosa infection, which will constitute an ideal platform to further study the role of macrophages in the context of CF. Copyright © 2024 Rodriguez Gonzalez, Basílio-Queirós, Neehus, Merkert, Tschritter, Ünal, Hegermann, Mörgelin, Bustamante, Nietert, Martin, Tümmler, Munder and Lachmann.
| Authors | Rodriguez Gonzalez C, Basílio-Queirós D, Neehus AL, Merkert S, Tschritter D, Ünal S, Hegermann J, Mörgelin M, Bustamante J, Nietert MM, Martin U, Tümmler B, Munder A, Lachmann N |
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| Journal | Frontiers in immunology |
| Publication Date | 2024;15:1397886 |
| PubMed | 39606224 |
| PubMed Central | PMC11601075 |
| DOI | 10.3389/fimmu.2024.1397886 |