Modeling Leukemia with Human Induced Pluripotent Stem Cells


The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development. Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

Authors Papapetrou EP
Journal Cold Spring Harbor perspectives in medicine
Publication Date 2019 Dec 2;9(12)
PubMed 31451537
PubMed Central PMC6886454
DOI 10.1101/cshperspect.a034868

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