Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Summary
In conclusion, the novel SBAD0201-derived BBB model formed tight monolayers and was proven useful for studies investigating GLUT-1, LAT-1, and LRP-1 mediated transport across the BBB. However, the model did not express functional P-gp and thus is not suitable for the performance of drug efflux P-gp reletated studies. © 2023. The Author(s).
| Authors | Ozgür B, Puris E, Brachner A, Appelt-Menzel A, Oerter S, Balzer V, Holst MR, Christiansen RF, Hyldig K, Buckley ST, Kristensen M, Auriola S, Jensen A, Fricker G, Nielsen MS, Neuhaus W, Brodin B |
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| Journal | Fluids and barriers of the CNS |
| Publication Date | 2023 Dec 19;20(1):96 |
| PubMed | 38115090 |
| PubMed Central | PMC10731806 |
| DOI | 10.1186/s12987-023-00501-9 |