Generation of an induced pluripotent stem cell line (UNCCi002-A) from a healthy donor using a non-integration system to study Cerebral Cavernous Malformation (CCM)


The generation of induced pluripotent stem cells (iPSCs) from healthy individuals is an invaluable resource as reference control in disease modeling and drug discovery. This paper details the reprogramming of peripheral blood mononuclear cells (PBMCs) isolated from a healthy 27 years-old male using non-integration technology. The derived iPSCs displayed typical pluripotent stem cell morphology, the capacity to differentiate into the three germ layers, and normal karyotype. This iPSC line will be used as a reference control to study the Cerebral Cavernous Malformation disease mechanism. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Beltran AA, Molina SG, Marquez A, Munoz LJ, Olivares JF, Beltran AS
Journal Stem cell research
Publication Date 2021 Jul;54:102421
PubMed 34130156
DOI 10.1016/j.scr.2021.102421

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