Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518 + 512 T > A variant in the DMD gene
Summary
Duchenne muscular dystrophy (DMD) is an X-linked recessive degenerative disease characterized by progressive weakness of limbs. In this study, we generated an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts with non-integrating Sendai virus. The patient carried a rare c.4518 + 512 T > A variant in the DMD gene. This iPSC line displayed normal iPSC morphology, karyotypes and pluripotency expression markers, and also can be differentiated into the three germ layers. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Jin M, Wang D, Li G, Lin J, Lin X, Wang N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Apr;60:102718 |
| PubMed | 35247844 |
| DOI | 10.1016/j.scr.2022.102718 |