Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518 + 512 T > A variant in the DMD gene

Summary

Duchenne muscular dystrophy (DMD) is an X-linked recessive degenerative disease characterized by progressive weakness of limbs. In this study, we generated an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts with non-integrating Sendai virus. The patient carried a rare c.4518 + 512 T > A variant in the DMD gene. This iPSC line displayed normal iPSC morphology, karyotypes and pluripotency expression markers, and also can be differentiated into the three germ layers. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Jin M, Wang D, Li G, Lin J, Lin X, Wang N
Journal Stem cell research
Publication Date 2022 Apr;60:102718
PubMed 35247844
DOI 10.1016/j.scr.2022.102718

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