Generation of human induced pluripotent stem cell line FDCHDPi001-A from a Chinese Han Tourette's syndrome patient


Tourette's syndrome (TS) is a childhood onset neuropsychiatric disorder. The underlying pathogenesis of TS remains unclear. A human induced pluripotent stem cell (hiPSC) line, derived from the peripheral blood mononuclear cells (PBMCs) from a TS patient, was generated by the reprogramming with episomal vectors expressing OCT4, SOX2, KLF4 and c-MYC. The generated hiPSC line is free of episomal vectors, with normal karyotype, expressing pluripotency markers and can differentiate into three germ layers in vivo. This hiPSC line from TS patient can offer a useful resource for studying the pathological mechanism of TS and screening effective drugs for therapeutic purpose. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Yuan A, Tao R, Yu S, Jing N, Sun J
Journal Stem cell research
Publication Date 2021 Apr;52:102227
PubMed 33607468
DOI 10.1016/j.scr.2021.102227

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