Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease
Summary
Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Li B, Yang Y, Wang Y, Shan D, Li J, Wang H, Sun X, Tang Y, Jiao Y, Ji X, Zhan Z, Kong B, Gao B, Wang Y, Sun P, Liu F |
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| Journal | Stem cell research |
| Publication Date | 2025 Feb;82:103638 |
| PubMed | 39729861 |
| DOI | 10.1016/j.scr.2024.103638 |