Modeling sporadic juvenile ALS in iPSC-derived motor neurons explores the pathogenesis of FUS(R503fs) mutation
Summary
iPSCs-derived motor neurons from JALS patients are promising tools for drug screening. The pathological changes in motor neurons of FUSR503fs may occur earlier than in other known mutation types that have been reported. Copyright © 2024 Chen, Chen, Zhang and Zhang.
| Authors | Chen L, Chen G, Zhang M, Zhang X |
|---|---|
| Journal | Frontiers in cellular neuroscience |
| Publication Date | 2024;18:1364164 |
| PubMed | 38711616 |
| PubMed Central | PMC11070534 |
| DOI | 10.3389/fncel.2024.1364164 |