Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
Summary
Our data provide stage-specific target genes of PDX1 during in vitro differentiation of stem cells into pancreatic progenitors that could be useful to identify pathways and molecular targets that predispose for diabetes. In addition, we show that T2DM-associated SNPs are enriched in active chromatin regions at the pancreatic progenitor stage, suggesting that the susceptibility to T2DM might originate from imperfect execution of a β-cell developmental program. Copyright © 2018 The Authors. Published by Elsevier GmbH.. All rights reserved.
| Authors | Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, Staiger H, Häring HU, Lederer G, Meitinger T, Cernilogar FM, Schotta G, Irmler M, Beckers J, Hrabě de Angelis M, Ray M, Wright CVE, Bakhti M, Lickert H |
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| Journal | Molecular metabolism |
| Publication Date | 2018 Mar;9:57-68 |
| PubMed | 29396371 |
| PubMed Central | PMC5870105 |
| DOI | 10.1016/j.molmet.2018.01.011 |