Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation
Summary
In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs). Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lavra L, Magi F, Ulivieri A, Morgante A, Paulis M, Sala L, Pedrazzini M, Polisca P, Rocchetti M, Calò L, Sciacchitano S, Salehi LB |
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| Journal | Stem cell research |
| Publication Date | 2021 Jul;54:102418 |
| PubMed | 34130155 |
| DOI | 10.1016/j.scr.2021.102418 |