Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation


In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs). Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Lavra L, Magi F, Ulivieri A, Morgante A, Paulis M, Sala L, Pedrazzini M, Polisca P, Rocchetti M, Calò L, Sciacchitano S, Salehi LB
Journal Stem cell research
Publication Date 2021 Jul;54:102418
PubMed 34130155
DOI 10.1016/j.scr.2021.102418

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