Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCs


Turner syndrome, caused by partial or complete loss of one copy of X-chromosome (45,X), is the most common sex chromosome abnormality in women with an incidence of 1 in 2500 female births. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) carrying X-monosomy anomaly, with isogenic control iPSCs. Among the iPSC lines generated from 46XX-fibroblasts, one spontaneously lost a copy of X-chromosome following the reprogramming process, establishing the 45X-iPSC line. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Feki A, Sloan-Béna F, Hibaoui Y
Journal Stem cell research
Publication Date 2020 Jul 22;47:101920
PubMed 32739879
DOI 10.1016/j.scr.2020.101920

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