Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3


Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Authors McNeill RV, Radtke F, Nieberler M, Koreny C, Chiocchetti AG, Kittel-Schneider S
Journal Stem cell research
Publication Date 2023 Mar;67:103016
PubMed 36640473
DOI 10.1016/j.scr.2023.103016

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