Generation of inducible pluripotent stem cell lines from Alzheimer's disease patients with APOE e3/e3 genotype


iPSCs were generated from B lymphocytes of two Alzheimer's disease (AD) patients homozygous for the APOE e3 allele. The iPSCs express pluripotency-specific markers and have the capacity to differentiate into all three embryonic germ layers. Karyotyping analyses confirmed the iPSCs have normal karyotypes. These iPSCs can be utilized as an in vitro model to study AD and to evaluate efficacies of new treatments. Copyright © 2021. Published by Elsevier B.V.

Authors Lee J, Liu Z, Tusing YG, Li C, Westin E, Li W, Zhao R
Journal Stem cell research
Publication Date 2021 Aug;55:102498
PubMed 34392011
PubMed Central PMC8496340
DOI 10.1016/j.scr.2021.102498

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