Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation


Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Niu S, Xiong H, Li Y, Zhang L
Journal Stem cell research
Publication Date 2020 Jul 15;47:101915
PubMed 32721895
DOI 10.1016/j.scr.2020.101915

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